Therapeutic Challenges of AIDS-Related Non-Hodgkin’s Lymphoma in the United States and East Africa

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dc.contributor.authorOtieno, Mwanda W.
dc.contributor.authorBanura, Cecily
dc.contributor.authorKatongole-Mbidde, Edward
dc.contributor.authorJohnson, John L.
dc.contributor.authorDowlati, Afshin
dc.contributor.authorRenne, Rolf
dc.contributor.authorArts, Eric
dc.contributor.authorWhalen, Christopher
dc.contributor.authorLederman, Michael M.
dc.contributor.authorRemick, Scot C.
dc.date.accessioned2022-02-11T00:13:51Z
dc.date.available2022-02-11T00:13:51Z
dc.date.issued2002-05
dc.description.abstractAbstract Non-Hodgkin's lymphoma (NHL) remains the second most common malignant complication in patients with human immunodeficiency virus (HIV) infection. As we enter the third decade of the acquired immunodeficiency syndrome (AIDS) epidemic, it is apparent that the evolution of antiretroviral therapy and the emergence of combination antiviral strategies have greatly affected the natural history of HIV infection and its neoplastic complications. For example, there may be a trend for declining incidence of AIDS-related lymphoma in the United States for the first time. However, in regions of the world where the burden of HIV infection is greatest, such as in East Africa, AIDS-related lymphoma is an increasing cause of morbidity and mortality. Treatment of lymphoma has evolved coincident with improvements in antiretroviral therapy. Infusional chemotherapy regimens may offer advantages over other regimens and schedules, but comparative trials have not been done. Clinical trial data are available on which to develop therapeutic strategies to treat this disease in East Africa where pragmatic approaches are needed. Both the differences in manifestations of HIV infection and the inherent difficulties in administering cytotoxic chemotherapy in this part of the world must be taken into consideration in planning therapeutic strategies. Improved understanding of the pathogenesis of HIV infection and lymphoma will likely yield improved therapeutic interventions as well.en_US
dc.identifier.citationOtieno MW, Banura C, Katongole-Mbidde E, Johnson JL, Ghannoum M, Dowlati A, Renne R, Arts E, Whalen C, Lederman MM, Remick SC. Therapeutic challenges of AIDS-related non-Hodgkin's lymphoma in the United States and East Africa. J Natl Cancer Inst. 2002 May 15;94(10):718-32. doi: 10.1093/jnci/94.10.718. PMID: 12011222.en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2053
dc.language.isoen_USen_US
dc.subjectTherapeutic challengesen_US
dc.subjectAIDSen_US
dc.subjectAIDS-related non-Hodgkin's lymphomaen_US
dc.subjectUnited Statesen_US
dc.subjectEast Africaen_US
dc.titleTherapeutic Challenges of AIDS-Related Non-Hodgkin’s Lymphoma in the United States and East Africaen_US
dc.typeArticleen_US
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