Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial

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dc.contributor.authorLuggya, Tonny S.
dc.contributor.authorRoche, Tony
dc.contributor.authorSsemogerere, Lameck
dc.contributor.authorKintu, Andrew
dc.contributor.authorKasumba, John M.
dc.contributor.authorKwizera, Arthur
dc.contributor.authorTindimwebwa, Jose V. B.
dc.date.accessioned2022-05-27T15:04:09Z
dc.date.available2022-05-27T15:04:09Z
dc.date.issued2017
dc.description.abstractSurgery and Anesthesia cause an excessive pro-inflammatory response. Mulago Hospital is faced with staff shortage making post-operative pain management difficult.Interleukin-6 (IL-6) drives inflammatory pain, endothelial cell dysfunction and fibrogenesis. Ketamine is cheap and, readily available. We hypothesized that its attenuation of serum IL-6 was a surrogate for clinical benefit. Materials and methods: Institutional Review Board’s approval was sought and RCT was registered at clinical trials.gov (identifier number: NCT01339065). Consenting patients were randomized to receive pre-incision intravenous ketamine - 0.5mg/kg or 0.9% saline placebo in weighted dosing. Blood samples were collected and laboratory analyzed at baseline, post-operatively in PACU, 24 and 48 hours respectively. Results: We recruited 39 patients of whom 18 were randomized to the ketamine arm and 21 in the placebo arm with follow up at 24 and 48 hours. Serum IL-6 and IL-1β levels were analyzed using ELIZA assay of pre-coated micro wells. Ketamine suppressed serum IL-6 at PACU with reduced increase at 24 hours. There was no reaction in 98% of IL-1β assayed. Conclusion: Low-dose ketamine attenuated early serum IL-6 levels due to surgical response with reduced 24 hour increase, but the difference was not statistically significant and we recommend more studiesen_US
dc.identifier.citationLuggya, T. S., Roche, T., Ssemogerere, L., Kintu, A., Kasumba, J. M., Kwizera, A., & Tindimwebwa, J. V. (2017). Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial. African Health Sciences, 17(2), 500-507.DOI: https://dx.doi.org/10.4314/ahs.v17i2.25en_US
dc.identifier.uriDOI: https://dx.doi.org/10.4314/ahs.v17i2.25
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3588
dc.language.isoenen_US
dc.publisherAfrican Health Sciencesen_US
dc.subjectKetamineen_US
dc.subjectpost-operative inflammationen_US
dc.subjectinterleukin 6en_US
dc.titleEffect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trialen_US
dc.typeArticleen_US
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