Incidence and risk factors for herpes simplex virus type 2 seroconversion among pregnant women in Uganda: A prospective study

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dc.contributor.authorNakubulwa, Sarah
dc.contributor.authorKaye, Dan K.
dc.contributor.authorBwanga, Freddie
dc.contributor.authorMbona Tumwesigye, Nazarius
dc.contributor.authorNakku-Joloba, Edith
dc.contributor.authorMirembe, Florence M.
dc.date.accessioned2022-01-21T19:44:39Z
dc.date.available2022-01-21T19:44:39Z
dc.date.issued2016
dc.description.abstractHerpes simplex virus type 2 (HSV-2) acquired during pregnancy is associated with adverse outcomes such as perinatal HSV-2 transmission. HSV-2 seroconversion occurs within four weeks of HSV-2 acquisition. There was neither documented incidence nor risk factors for HSV-2 seroconversion during pregnancy in Uganda. The objective of this study was to determine the incidence and risk factors for HSV-2 seroconversion among pregnant women in Mulago Hospital, Uganda. Methodology: A prospective study of 200 consenting HSV-2-negative women between 26 and 28 weeks of gestation was done between November 2013 and October 2014. HSV-2 serostatus was determined using HerpeSelect HSV-2 enzyme-linked immunosorbent assay (ELISA). Interviewer-administered questionnaires were used to collect socio-demographic characteristics and sexual history. Human immunodeficiency virus (HIV) serostatus was obtained from antenatal records. A total of 191 women completed follow-up and repeat HSV-2 serology by 38 weeks. Negative binomial regression analysis was used to estimate risk ratios for risk factors for HSV-2 seroconversion. Results: Of 191 women, 15 (7.9%) seroconverted during pregnancy. Having multiple sexual partners, being in polygamous unions, and having HIV-positive serostatus were found to be risk factors for HSV-2 seroconversion. Conclusions: The incidence of HSV-2 seroconversion during pregnancy in Uganda was high. Multiple sexual partners, polygamy, and HIV-positive serostatus were risk factors for HSV-2 seroconversion during pregnancy. Strengthening health education on the avoidance of multiple sexual partners during pregnancy is paramount in prevention of HSV-2 seroconversion.en_US
dc.identifier.citationNakubulwa, S., Kaye, D. K., Bwanga, F., Tumwesigye, N. M., Nakku-Joloba, E., & Mirembe, F. M. (2016). Incidence and risk factors for herpes simplex virus type 2 seroconversion among pregnant women in Uganda: A prospective study. The Journal of Infection in Developing Countries, 10(10), 1108-1115. doi:10.3855/jidc.6874en_US
dc.identifier.other10.3855/jidc.6874
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1397
dc.language.isoenen_US
dc.publisherThe Journal of Infection in Developing Countriesen_US
dc.subjectHerpes simplex virus type 2en_US
dc.subjectIncidenceen_US
dc.subjectSeroconversionen_US
dc.subjectPregnancyen_US
dc.subjectRisk factorsen_US
dc.titleIncidence and risk factors for herpes simplex virus type 2 seroconversion among pregnant women in Uganda: A prospective studyen_US
dc.typeArticleen_US
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