The effect of biomass smoke exposure on quality-of-life among Ugandan patients treated for tuberculosis: A cross-sectional analysis

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dc.contributor.authorWennemann, Sophie
dc.contributor.authorMudarshiru, Bbuye
dc.contributor.authorZawedde-Muyanja, Stella
dc.contributor.authorSiddharthan, Trishul
dc.contributor.authorJackson, Peter D
dc.date.accessioned2024-02-14T10:13:33Z
dc.date.available2024-02-14T10:13:33Z
dc.date.issued2024-02
dc.description.abstractAbstract More than half the global population burns biomass fuels for cooking and home heating, especially in low-middle income countries. This practice is a prominent source of indoor air pollution and has been linked to the development of a variety of cardiopulmonary diseases, including Tuberculosis (TB). The purpose of this cross-sectional study was to investigate the association between current biomass smoke exposure and self-reported quality of life scores in a cohort of previous TB patients in Uganda. We reviewed medical records from six TB clinics from 9/2019-9/2020 and conducted phone interviews to obtain information about biomass smoke exposure. A random sample of these patients were asked to complete three validated quality-of-life surveys including the St. Georges Respiratory Questionnaire (SGRQ), the EuroQol 5 Dimension 3 Level system (EQ-5D-3L) which includes the EuroQol Visual Analog Scale (EQ-VAS), and the Patient Health Questionnaire 9 (PHQ-9). The cohort was divided up into 3 levels based on years of smoke exposure–no-reported smoke exposure (0 years), light exposure (1–19 years), and heavy exposure (20+ years), and independent-samples-Kruskal-Wallis testing was performed with post-hoc pairwise comparison and the Bonferroni correction. The results of this testing indicated significant increases in survey scores for patients with current biomass exposure and a heavy smoke exposure history (20 + years) compared to no reported smoke exposure in the SGRQ activity scores (adj. p = 0.018) and EQ-5D-3L usual activity scores (adj. p = 0.002), indicating worse activity related symptoms. There was a decrease in EQ-VAS scores for heavy (adj. p = 0.007) and light (adj. p = 0.017) exposure groups compared to no reported exposure, indicating lower perceptions of overall health. These results may suggest worse outcomes or baseline health for TB patients exposed to biomass smoke at the time of treatment and recovery, however further research is needed to characterize the effect of indoor air pollution on TB treatment outcomes.en_US
dc.description.sponsorshipFunder Name: NIH, CTSA award No. UL1TR002649 from the National Center for Advancing Translational Sciences to support data collection (P.J.) Funder Name: CHEST Foundation Grant Number: Chest Foundation/ATS Research Grant in COVID and Diversity Grant Recipient: Dr Peter Durham Jackson Funder Name: American Thoracic Society Grant Number: Chest Foundation/ATS Research Grant in COVID and Diversity Grant Recipient: Dr Peter Durham Jackson Funder Name: School of Medicine, Virginia Commonwealth University Grant Number: DOIM Pilot Grant Grant Recipient: Dr Peter Durham Jackson The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.citationWennemann, Sophie, Bbuye Mudarshiru, Stella Zawedde-Muyanja, et al. 'The Effect of Biomass Smoke Exposure on Quality-of-Life among Ugandan Patients Treated for Tuberculosis: A Cross-Sectional Analysis', PLOS Global Public Health, vol. 4/no. 2, (2024), pp. e0002892.en_US
dc.identifier.issnEISSN 2767-3375
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9407
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.subjectTuberculosis; Smoking habits ; Smoking related disorders; Quality of lifeen_US
dc.titleThe effect of biomass smoke exposure on quality-of-life among Ugandan patients treated for tuberculosis: A cross-sectional analysisen_US
dc.typeArticleen_US
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