Evaluation of underweight status may improve identification of the highest-risk patients during outpatient evaluation for pulmonary tuberculosis

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dc.contributor.authorKitonsa, Peter J.
dc.contributor.authorNalutaaya, Annet
dc.contributor.authorMukiibi, James
dc.contributor.authorNakasolya, Olga
dc.contributor.authorIsooba, David
dc.contributor.authorKamoga, Caleb
dc.contributor.authorBaik, Yeonsoo
dc.contributor.authorRobsky, Katherine
dc.contributor.authorDowdy, David W.
dc.contributor.authorKatamba, Achilles
dc.contributor.authorKendall, Emily A.
dc.date.accessioned2023-01-14T19:06:24Z
dc.date.available2023-01-14T19:06:24Z
dc.date.issued2020
dc.description.abstractWhen evaluating symptomatic patients for tuberculosis (TB) without access to same-day diagnostic test results, clinicians often make empiric decisions about starting treatment. The number of TB symptoms and/or underweight status could help identify patients at highest risk for a positive result. We sought to evaluate the usefulness of BMI assessment and a count of characteristic TB symptoms for identifying patients at highest risk for TB. Methods We enrolled adult patients receiving pulmonary TB diagnoses and a representative sample with negative TB evaluations at four outpatient health facilities in Kampala, Uganda. We asked patients about symptoms of chronic cough, night sweats, chest pain, fever, hemoptysis, or weight loss; measured height and weight; and collected sputum for mycobacterial culture. We evaluated the diagnostic accuracy (for culture-positive TB) of two simple scoring systems: (a) number of TB symptoms, and (b) number of TB symptoms plus one or more additional points for underweight status (body mass index [BMI] � 18.5 kg/m2). Results We included 121 patients with culture-positive TB and 370 patients with negative culture results (44 of whom had been recommended for TB treatment by evaluating clinicians). Of the six symptoms assessed, the median number of symptoms that patients reported was two (interquartile range [IQR]: 1, 3). The median BMI was 20.9 kg/m2 (IQR: 18.6, 24.0), and 118 (24%) patients were underweight. Counting the number of symptoms provided an areaen_US
dc.identifier.citationKitonsa PJ, Nalutaaya A, Mukiibi J, Nakasolya O, Isooba D, Kamoga C, et al. (2020) Evaluation of underweight status may improve identification of the highest-risk patients during outpatient evaluation for pulmonary tuberculosis. PLoS ONE 15(12): e0243542. https://doi.org/ 10.1371/journal.pone.0243542en_US
dc.identifier.urihttps://doi.org/ 10.1371/journal.pone.0243542
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/6926
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectPatientsen_US
dc.subjectOutpatient evaluationen_US
dc.subjectPulmonary tuberculosisen_US
dc.titleEvaluation of underweight status may improve identification of the highest-risk patients during outpatient evaluation for pulmonary tuberculosisen_US
dc.typeArticleen_US
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