Distribution of yeast species associated with oral lesions in HIV-infected patients in Southwest Uganda
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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
Medical Mycology
Abstract
Oropharyngeal candidiasis remains a signifi cant clinical problem in HIV-infected and AIDS patients in regions of Africa where anti-retroviral therapy isn ’ t readily available. In this study we identifi ed the yeast populations associated with oral lesions
in HIV-infected patients in Southwest Uganda who were receiving treatment with nystatin and topical clotrimazole. Samples were taken from 605 patients and 316 (52%) of these yielded yeast growth following incubation on Sabouraud dextrose
agar. Samples were subsequently re-plated on CHROMagar Candida medium to facilitate identifi cation of the yeast species pr esent. The majority (56%) of culturepositivesamples yielded a mix of two or more species. Candida albicans was present
in 87% (274/316) of patient samples and accounted for 87% (120/138) of single species samples. Candida glabrata , Candida tropicalis and Candida norvegensis were also found in cultures that yielded a single species. No Candida dubliniensis
isolates were identifi ed in this population.
Description
Keywords
prevalence, yeast species, Candida, HIV, oropharyngeal
Citation
Agwu, E., Ihongbe, J. C., McManus, B. A., Moran, G. P., Coleman, D. C., & Sullivan, D. J. (2012). Distribution of yeast species associated with oral lesions in HIV-infected patients in Southwest Uganda. Medical Mycology, 50(3), 276-280.