Resistance Testing for Management of HIV Virologic Failure in Sub-Saharan Africa

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dc.contributor.authorSiedner, Mark J.
dc.contributor.authorMoosa, Mahomed-Yunus S.
dc.contributor.authorMcCluskey, Suzanne
dc.contributor.authorGilbert, Rebecca F.
dc.contributor.authorPillay, Selvan
dc.contributor.authorAturinda, Isaac
dc.contributor.authorArd, Kevin
dc.contributor.authorMuyindike, Winnie
dc.contributor.authorMusinguzi, Nicholas
dc.contributor.authorMasette, Godfrey
dc.contributor.authorPillay, Melendhran
dc.contributor.authorMoodley, Pravikrishnen
dc.contributor.authorBrijkumar, Jaysingh
dc.contributor.authorRautenberg, Tamlyn
dc.contributor.authorGeorge, Gavin
dc.contributor.authorGandhi, Rajesh T.
dc.contributor.authorJohnson, Brent A.
dc.contributor.authorSunpath, Henry
dc.contributor.authorBwana, Mwebesa B.
dc.contributor.authorMarconi, Vincent C.
dc.date.accessioned2022-01-16T11:49:12Z
dc.date.available2022-01-16T11:49:12Z
dc.date.issued2021
dc.description.abstractVirologic failure in HIV remains a major public health threat in sub-Saharan Africa. It occurs in approximately 10% to 30% of patients within 2 years of antiretroviral therapy (ART) initiation and is associated with development of drug resistance, increased risk for opportunistic infections and death, and ongoing transmission of HIV (1–6). The optimal management of virologic failure is unknown. Guidelines published by the U.S. Department of Health and Human Services recommend genotypic resistance testing (GRT) to assist in the management of virologic failure (7). Small randomized trials and observational studies completed in the early ART era in the United States suggested that GRT has benefit in virologic control and selection of active regimens (8–11). However, GRT after failure of first-line therapy is not routinely supported by treatment guidelines by the World Health Organization and is not typically done in most sub-Saharan African countries (12).en_US
dc.identifier.citationSiedner, M. J., Moosa, M. Y. S., McCluskey, S., Gilbert, R. F., Pillay, S., Aturinda, I., ... & Marconi, V. C. (2021). Resistance Testing for Management of HIV Virologic Failure in Sub-Saharan Africa: An Unblinded Randomized Controlled Trial. Annals of Internal Medicine, 174(12), 1683-1692. doi:10.7326/M21-2229en_US
dc.identifier.other10.7326/M21-2229
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1301
dc.language.isoenen_US
dc.publisherAnnals of Internal Medicineen_US
dc.subjectTestingen_US
dc.subjectHIV Virologic Failureen_US
dc.subjectSub-Saharan Africaen_US
dc.titleResistance Testing for Management of HIV Virologic Failure in Sub-Saharan Africaen_US
dc.typeArticleen_US
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