Medicinal Plants Used in the Management of Sexual Dysfunction, Infertility and Improving Virility in the East African Community: A Systematic Review

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dc.contributor.authorKyarimpa, Christine
dc.contributor.authorNagawa, Christine Betty
dc.contributor.authorOmara, Timothy
dc.contributor.authorSsebugere, Patrick
dc.contributor.authorLugasi, Solomon Omwoma
dc.contributor.authorGumula, Ivan
dc.date.accessioned2025-02-24T14:45:25Z
dc.date.available2025-02-24T14:45:25Z
dc.date.issued2023-08-12
dc.description.abstractSexual disorders such as erectile dysfunction (ED), sterility, and sexual inappetence represent some of the complex reproductive challenges that require addressing the underlying causes. The aim of this paper was to systematically synthesize literature on the ethnobotany, phytochemistry, bioactivities, and safety of plants used as remedies for managing sexual dysfunction and infertility, and improving fertility and virility in the EAC. Through an extensive review conducted in multidisciplinary electronic databases, 171 plant species were identified to have been reported for the management of sexual inappetence (i.e., used as aphrodisiacs, 39.4%), ED (35.9%), infertility (18.7%), and increasing fertility (6.0%). The most used plants are Mondia whitei, Acalypha villicaulis, Combretum illairii, Erythrina abyssinica, Pappea capensis, Rhus vulgaris, and Warburgia ugandensis while roots (44.9%), leaves (21.8%), stem and root barks (16.7%) of shrubs (35%), trees (31%), herbs (26%), and climbers (8%) are the preferred organs for making decoctions (69%). The research strides to date indicate that Citropsis articulata, Cola acuminata, Ekebergia capensis, Plumbago zeylanica, Tarenna graveolens, Urtica massaica, and Zingiber officinale have been assessed for their bioactivity. The majority (71.4%) of the plants either increased testosterone levels and mounting frequency or elicited prosexual stimulatory effects in male rats. More studies investigating the relevant pharmacological activities (aphrodisiac, fertility, and phosphodiesterase-5 inhibitory activities), safety aspects, responsible compounds, and clinical studies are warranted to establish the pharmacological potential of the unstudied species and elucidate the mechanism of action of the bioactive compounds.
dc.identifier.citationKyarimpa, C., Nagawa, C. B., Omara, T., Odongo, S., Ssebugere, P., Lugasi, S. O., & Gumula, I. (2023). Medicinal plants used in the management of sexual dysfunction, infertility and improving virility in the East African Community: a systematic review. Evidenceā€Based Complementary and Alternative Medicine, 2023(1), 6878852.https://doi.org/10.1155/2023/6878852
dc.identifier.otherhttps://doi.org/10.1155/2023/6878852
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9997
dc.language.isoen
dc.publisherEvidenceā€Based Complementary and Alternative Medicine,
dc.titleMedicinal Plants Used in the Management of Sexual Dysfunction, Infertility and Improving Virility in the East African Community: A Systematic Review
dc.typeArticle
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