African Burkitt Lymphoma: Age-Specific Risk and Correlations with Malaria Biomarkers

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dc.contributor.authorEmmanuel, Benjamin
dc.contributor.authorKawira, Esther
dc.contributor.authorOgwang, Martin D.
dc.contributor.authorWabinga, Henry
dc.contributor.authorMagatti, Josiah
dc.contributor.authorNkrumah, Francis
dc.contributor.authorNeequaye, Janet
dc.contributor.authorBhatia, Kishor
dc.contributor.authorBrubaker, Glen
dc.contributor.authorBiggar, Robert J.
dc.contributor.authorMbulaiteye, Sam M.
dc.date.accessioned2022-04-29T13:36:32Z
dc.date.available2022-04-29T13:36:32Z
dc.date.issued2011
dc.description.abstractAfrican Burkitt lymphoma is an aggressive B-cell, non-Hodgkin lymphoma linked to Plasmodium falciparum malaria. Malaria biomarkers related to onset of African Burkitt lymphoma are unknown. We correlated agespecific patterns of 2,602 cases of African Burkitt lymphoma (60% male, mean ± SD age = 7.1 ± 2.9 years) from Uganda, Ghana, and Tanzania with malaria biomarkers published from these countries. Age-specific patterns of this disease and mean multiplicity of P. falciparum malaria parasites, defined as the average number of distinct genotypes per positive blood sample based on the merozoite surface protein-2 assessed by polymerase chain reaction, were correlated and both peaked between 5 and 9 years. This pattern, which was strong and consistent across regions, contrasted parasite prevalence, which peaked at 2 years and decreased slightly, and geometric mean parasite density, which peaked between 2 and 3 years and decreased sharply. Our findings suggest that concurrent infection with multiple malaria genotypes may be related to onset of African Burkitt lymphoma.en_US
dc.identifier.citationEmmanuel, B., Kawira, E., Ogwang, M. D., Wabinga, H., Magatti, J., Nkrumah, F., ... & Mbulaiteye, S. M. (2011). African Burkitt lymphoma: age-specific risk and correlations with malaria biomarkers. The American journal of tropical medicine and hygiene, 84(3), 397. doi:10.4269/ajtmh.2011.10-0450en_US
dc.identifier.other10.4269/ajtmh.2011.10-0450
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/2973
dc.language.isoenen_US
dc.publisherThe American journal of tropical medicine and hygieneen_US
dc.subjectAfrican Burkitt Lymphomaen_US
dc.subjectAge-Specific Risken_US
dc.subjectMalaria Biomarkersen_US
dc.titleAfrican Burkitt Lymphoma: Age-Specific Risk and Correlations with Malaria Biomarkersen_US
dc.typeArticleen_US
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