Relation Between Chemokine Receptor Use, Disease Stage, and HIV-1 Subtypes A and D Results From a Rural Ugandan Cohort

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dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorNankya, Immaculate L.
dc.contributor.authorYirrell, David L.
dc.contributor.authorShafer, Leigh Anne
dc.contributor.authorKyosiimire-Lugemwa, Jacqueline
dc.contributor.authorLule, Daniel B.
dc.contributor.authorMorgan, Dilys
dc.contributor.authorBeddows, Simon
dc.contributor.authorWeber, Jonathan
dc.contributor.authorWhitworth, James A. G.
dc.date.accessioned2022-01-05T10:48:37Z
dc.date.available2022-01-05T10:48:37Z
dc.date.issued2007
dc.description.abstractTo determine whether there are differences in coreceptor use in subjects infected with HIV-1 envelope subtypes A and D that could explain the differences in progression rates between these subtypes in a rural Ugandan cohort. HIV-1 was subtyped in env by V3 sequencing or heteroduplex mobility assay. Coreceptor use was determined by the ability of the isolates to replicate in U87 CD4+ cells expressing different coreceptors. The Fisher exact test was used to examine the relation between coreceptor use and subtype, clinical stage, and V3 charge. The Kruskall-Wallis nonparametric test was used to examine the association between median CD4 cell counts, coreceptor use, and subtype. Logistic regression was used to examine predicted coreceptor use at different CD4 groupings. Isolates from 66 participants were analyzed. Thirty-one were infected with subtype A, and 35 were infected with subtype D. Although this work was based on a small sample size, we found statistically significant differences. The probability of having an X4 virus was higher in subtype D infections than in subtype A infections among those with a non-AIDS clinical status (Fisher exact test, P = 0.040). Logistic regression analysis, in which we predicted X4 use by subtype and stratified by CD4 group, confirmed these findings among those with a CD4 count .200 cells/mL (likelihood ratio test, P = 0.003). R5 viruses were associated with higher median CD4 cell counts than X4 or X4/R5 (Kruskall-Wallis test, P = 0.0045). AV3 charge of +5 and greater was highly associated with X4 virus (Fisher exact test, P = 0.006). These subtype differences in coreceptor use may partially explain the faster progression rates we have previouslyen_US
dc.identifier.citationKaleebu, P., Nankya, I. L., Yirrell, D. L., Shafer, L. A., Kyosiimire-Lugemwa, J., Lule, D. B., ... & Whitworth, J. A. (2007). Relation between chemokine receptor use, disease stage, and HIV-1 subtypes A and D: results from a rural Ugandan cohort. JAIDS Journal of Acquired Immune Deficiency Syndromes, 45(1), 28-33.DOI:10.1097/QAI.0b013e3180385aa0en_US
dc.identifier.uri10.1097/QAI.0b013e3180385aa0
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1074
dc.language.isoenen_US
dc.publisherJAIDS Journal of Acquired Immune Deficiency Syndromesen_US
dc.relation.ispartofseriesJAIDS Journal of Acquired Immune Deficiency Syndromes;45(1)
dc.subjectcoreceptor useen_US
dc.subjectHIV-1en_US
dc.subjectSubtypes A and Den_US
dc.titleRelation Between Chemokine Receptor Use, Disease Stage, and HIV-1 Subtypes A and D Results From a Rural Ugandan Cohorten_US
dc.typeArticleen_US
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