High rates of culture conversion and low loss to follow‑up in MDR‑TB patients managed at Regional Referral Hospitals in Uganda

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dc.contributor.authorKayitale Martin, Mbonye
dc.contributor.authorOtuba, John Paul
dc.contributor.authorSara, Riese
dc.contributor.authorHilary, Alima
dc.contributor.authorMugabe, Frank
dc.contributor.authorMuhwezi, K. Augustin
dc.contributor.authorTuryahabwe, Stavia
dc.contributor.authorWandera, Christopher
dc.contributor.authorTisna, Veldhuijzen van Zanten
dc.contributor.authorTugume, Gladys
dc.date.accessioned2023-01-27T14:35:46Z
dc.date.available2023-01-27T14:35:46Z
dc.date.issued2021
dc.description.abstractMulti-drug resistant—tuberculosis (MDR-TB) is an emerging public health concern in Uganda. Prior to 2013, MDR-TB treatment in Uganda was only provided at the national referral hospital and two private-not-for profit clinics. From 2013, it was scaled up to seven regional referral hospitals (RRH). The aim of this study was to measure interim (6 months) treatment outcomes among the first cohort of patients started on MDR-TB treatment at the RRH in Uganda. Methods: This was a cross-sectional study in which a descriptive analysis of data collected retrospectively on a cohort of 69 patients started on MDR-TB treatment at six of the seven RRH between 1st April 2013 and 30th June 2014 and had been on treatment for at least 9 months was conducted. Results: Of the 69 patients, 21 (30.4%) were female, 39 (56.5%) HIV-negative, 30 (43.5%) resistant to both isoniazid and rifampicin and 57 (82.6%) category 1 or 2 drug susceptible TB treatment failures. Median age at start of treatment was 35 years (Interquartile range (IQR): 27–45), median time-to-treatment initiation was 27.5 (IQR: 6–89) days and of the 30 HIV-positive patients, 27 (90.0%) were on anti-retroviral treatment with a median CD4 count of 206 cells/ microliter of blood (IQR: 113–364.5). Within 6 months of treatment, 59 (85.5%) patients culture converted, of which 45 (65.2%) converted by the second month and the other 14 (20.3%) by the sixth month; one (1.5%) did not culture convert; three (4.4%) died; and six (8.8%) were lost-to-follow up. Fifty (76.8%) patients experienced at least one drug adverse event, while 40 (67.8%) gained weight. Mean weight gained was 4.7 (standard deviation: 3.2) kilograms. Conclusions: Despite MDR-TB treatment initiation delays, most patients had favourable interim treatment outcomes with majority culture converting early and very few getting lost to follow-up. These encouraging interim outcomes indicate the potential for success of a scale-up of MDR-TB treatment to RRH.en_US
dc.identifier.citationMartin, M. K., Paul, O. J., Sara, R., Hilary, A., Frank, M., Augustin, M. K., ... & Gladys, T. (2021). High rates of culture conversion and low loss to follow-up in MDR-TB patients managed at Regional Referral Hospitals in Uganda. BMC Infectious Diseases, 21(1), 1-9. https://doi.org/10.1186/s12879-021-06743-yen_US
dc.identifier.urihttps://doi.org/10.1186/s12879-021-06743-y
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7328
dc.language.isoenen_US
dc.publisherBMC Infectious Diseasesen_US
dc.subjectMulti-drug resistant tuberculosisen_US
dc.subjectRegional referral hospitalsen_US
dc.titleHigh rates of culture conversion and low loss to follow‑up in MDR‑TB patients managed at Regional Referral Hospitals in Ugandaen_US
dc.typeArticleen_US
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