Pertussis Prevalence and Its Determinants among Children with Persistent Cough in Urban Uganda

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dc.contributor.authorKayina, Vincent
dc.contributor.authorKyobe, Samuel
dc.contributor.authorKatabazi, Fred A.
dc.contributor.authorKigozi, Edgar
dc.contributor.authorOkee, Moses
dc.contributor.authorOdongkara, Beatrice
dc.contributor.authorBabikako, Harriet M.
dc.contributor.authorWhalen, Christopher C.
dc.contributor.authorJoloba, Moses L.
dc.contributor.authorMusoke, Philippa M.
dc.contributor.authorMupere, Ezekiel
dc.date.accessioned2022-05-02T21:49:45Z
dc.date.available2022-05-02T21:49:45Z
dc.date.issued2015
dc.description.abstractWe determined prevalence of pertussis infection and its associated host and environmental factors to generate information that would guide strategies for disease control. Methods In a cross-sectional study, 449 children aged 3 months to 12 years with persistent cough lasting 14 days were enrolled and evaluated for pertussis using DNA polymerase chain reaction (PCR) and ELISA serology tests. Results Pertussis prevalence was 67 (15% (95% Confidence Interval (CI): 12–18)) and 81 (20% (95% CI: 16–24)) by PCR and ELISA, respectively among 449 participating children. The prevalence was highest in children with >59 months of age despite high vaccination coverage of 94% in this age group. Study demographic and clinical characteristics were similar between pertussis and non-pertussis cases. Of the 449 children, 133 (30%) had a coughing household member and 316 (70%) did not. Among 133 children that had a coughing household member, sex of child, sharing bed with a coughing household member and having a coughing individual in the neighborhood were factors associated with pertussis. Children that had shared a bed with a coughing household individual had seven-fold likelihood of having pertussis compared to children that did not (odds ratio (OR) 7.16 (95% CI: 1.24– 41.44)). Among the 316 children that did not have a coughing household member, age <23 months, having or contact with a coughing individual in neighborhood, a residence with one room, and having a caretaker with >40 years of age were the factors associated with pertussis. Age <23months was three times more likely to be associated with pertussis compared to age 24–59 months (OR 2.97 (95% CI: 1.07–8.28)). Conclusion Findings suggest high prevalence of pertussis among children with persistent cough at a health facility and it was marked in children >59 months of age, suggesting the possibility of waning immunity. The factors associated with pertussis varied by presence or absence of a coughing household member.en_US
dc.identifier.citationKayina V, Kyobe S, Katabazi FA, Kigozi E, Okee M, Odongkara B, et al. (2015) Pertussis Prevalence and Its Determinants among Children with Persistent Cough in Urban Uganda. PLoS ONE 10(4): e0123240. doi:10.1371/journal.pone.0123240en_US
dc.identifier.other10.1371/journal.pone.0123240
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3167
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectPertussis Prevalenceen_US
dc.subjectDeterminants among Childrenen_US
dc.subjectCoughen_US
dc.subjectUrban Ugandaen_US
dc.titlePertussis Prevalence and Its Determinants among Children with Persistent Cough in Urban Ugandaen_US
dc.typeArticleen_US
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