Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda

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dc.contributor.authorJuan, Ravell
dc.contributor.authorOtim, Isaac
dc.contributor.authorNabalende, Hadijah
dc.contributor.authorLegason, Ismail D.
dc.contributor.authorReynolds, Steven J.
dc.contributor.authorOgwang, Martin D.
dc.contributor.authorNdugwa, Christopher M.
dc.contributor.authorMarshall, Vickie
dc.contributor.authorWhitby, Denise
dc.contributor.authorGoedert, James J.
dc.contributor.authorEngels, Eric A.
dc.contributor.authorBhatia, Kishor
dc.contributor.authorLenardo, Michael J.
dc.contributor.authorMbulaiteye, Sam M.
dc.date.accessioned2022-04-29T15:04:28Z
dc.date.available2022-04-29T15:04:28Z
dc.date.issued2018
dc.description.abstractEpstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda. Methods: Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors. Results: Plasma Mg2+ deficiency (plasma level<1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration. Interpretation: Plasma Mg2+ deficiency is associated with high EBV levels and eBL.en_US
dc.identifier.citationJuan, R., Otim, I., Nabalende, H., Legason, I. D., Reynolds, S. J., Ogwang, M. D., ... & Mbulaiteye, S. M. (2018). Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda. Cancer epidemiology, 52, 70-74. https://doi.org/10.1016/j.canep.2017.12.004en_US
dc.identifier.urihttps://doi.org/10.1016/j.canep.2017.12.004
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/2989
dc.language.isoenen_US
dc.publisherCancer epidemiology,en_US
dc.subjectEpstein-Barr virusen_US
dc.subjectBurkitt lymphomaen_US
dc.subjectMagnesiumen_US
dc.subjectXMEN Africaen_US
dc.subjectEpidemiologyen_US
dc.titlePlasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Ugandaen_US
dc.typeArticleen_US
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