Prevalence of elevated liver transaminases and their relationship with alcohol use in people living with HIV on anti-retroviral therapy in Uganda

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dc.contributor.authorFreiman, J. Morgan
dc.contributor.authorFatch, Robin
dc.contributor.authorCheng, Debbie
dc.contributor.authorEmenyonu, Nneka
dc.contributor.authorNgabirano, Christine
dc.contributor.authorGeadas, Carolina
dc.contributor.authorAdong, Julian
dc.contributor.authorMuyindike, Winnie R.
dc.contributor.authorLinas, Benjamin P.
dc.contributor.authorJacobson, Karen R.
dc.contributor.authorHahn, Judith A.
dc.date.accessioned2022-01-30T20:34:44Z
dc.date.available2022-01-30T20:34:44Z
dc.date.issued2021
dc.description.abstractIsoniazid preventive therapy (IPT) reduces tuberculosis reactivation and mortality among persons living with HIV (PLWH), yet hepatotoxicity concerns exclude “regular and heavy alcohol drinkers” from IPT. We aimed to determine the prevalence of elevated liver transaminases among PLWH on antiretroviral therapy (ART) who engage in alcohol use. The Immune Suppression Syndrome Clinic of Mbarara, Uganda. We defined elevated liver transaminases as 1.25 times (X) the upper limit of normal (ULN) for alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST). We evaluated the associations of current alcohol use and other variables of interest (sex, body mass index, and ART regimen) with elevated transaminases at study screening, using multivariable logistic regression to obtain adjusted odds ratios (aOR) and 95% confidence intervals (CI)en_US
dc.identifier.citationFreiman JM, Fatch R, Cheng D, Emenyonu N, Ngabirano C, Geadas C, et al. (2021) Prevalence of elevated liver transaminases and their relationship with alcohol use in people living with HIV on anti-retroviral therapy in Uganda. PLoS ONE 16(6): e0250368. https://doi.org/10.1371/ journal.pone.0250368en_US
dc.identifier.urihttps://doi.org/10.1371/ journal.pone.0250368
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1639
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectLiver transaminasesen_US
dc.subjectAlcohol useen_US
dc.subjectPeople living with HIVen_US
dc.subjectAnti-retroviral therapyen_US
dc.subjectUgandaen_US
dc.titlePrevalence of elevated liver transaminases and their relationship with alcohol use in people living with HIV on anti-retroviral therapy in Ugandaen_US
dc.typeArticleen_US
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