The epidemiology of rotavirus disease in under-five-year-old children hospitalized with acute diarrhea in central Uganda, 2012-2013
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Archives of virology
Abstract
A cross-sectional study was undertaken during 2012-2013 to determine the prevalence, strains and factors associated with rotavirus infection among under-5-year-old children hospitalized with acute diarrhea in Uganda. Rotaviruses were detected in 37 % (263/712) of the children. The most prevalent strains were G9P[8] (27 %, 55/204) and G12P[4] (18.6 %, 38/204). Mixed infections were detected in 22.5 % (46/204) of the children. The study suggests that consumption of raw vegetables (OR = 1.45, 95 % CI = 1.03-2.03) and family ownership of dogs (OR = 1.9, 95 % CI = 1.04-3.75) increases the risk of rotavirus infection. The study findings will be used to assess the impact of RV vaccination in Uganda.
Description
Keywords
Rotavirus, Genotyping, Mixed infections, Reassortment, Food hygiene, Zoonotic transmission
Citation
Bwogi, J., Malamba, S., Kigozi, B., Namuwulya, P., Tushabe, P., Kiguli, S., ... & Karamagi, C. (2016). The epidemiology of rotavirus disease in under-five-year-old children hospitalized with acute diarrhea in central Uganda, 2012-2013. Archives of virology, 161(4), 999-1003. DOI 10.1007/s00705-015-2742-2