Hyperglycemia in pregnancy diagnosed using glycated hemoglobin (HbA1c) in Uganda: a preliminary cross-sectional report [version 1; peer review: 1 approved]

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dc.contributor.authorBongomin, Felix
dc.contributor.authorKyazze, Andrew P.
dc.contributor.authorNinsiima, Sandra
dc.contributor.authorOlum, Ronald
dc.contributor.authorNattabi, Gloria
dc.contributor.authorNabakka, Winnie
dc.contributor.authorKukunda, Rebecca
dc.contributor.authorBatte, Charles
dc.contributor.authorSsekamatte, Phillip
dc.contributor.authorBaruch Baluku, Joseph
dc.contributor.authorKibirige, Davis
dc.contributor.authorCose, Stephen
dc.contributor.authorAndia-Biraro, Irene
dc.date.accessioned2023-01-22T17:22:08Z
dc.date.available2023-01-22T17:22:08Z
dc.date.issued2020
dc.description.abstractHyperglycemia in pregnancy (HIP) is a common medical complication during pregnancy and is associated with several short and long-term maternal-fetal consequences. We aimed to determine the prevalence and factors associated with HIP among Ugandan women. Methods: We consecutively enrolled eligible pregnant women attending antenatal care at Kawempe National Referral Hospital, Kampala, Uganda in September 2020. Mothers known to be living with diabetes mellitus or haemoglobinopathies and those with anemia (hemoglobin <11g/dl) were excluded. Random blood sugar (RBS) and glycated hemoglobin A1c (HbA1c) were measured on peripheral venous blood samples. HIP was defined as an HbA1c ≥5.7% with its subsets of diabetes in pregnancy (DIP) and prediabetes defined as HbA1c of ≥6.5% and 5.7-6.4% respectively. ROC curve analysis was performed to determine the optimum cutoff of RBS to screen for HIP. Results: A total of 224 mothers with a mean (± SD) age 26±5 years were enrolled, most of whom were in the 2nd or 3rd trimester (94.6%, n=212) with a mean gestation age of 26.6±7.3 weeks. Prevalence of 6HIP was 11.2% (n=25) (95% CI: 7.7-16.0). Among the mothers with HIP, 2.2% (n=5) had DIP and 8.9% (n=20) prediabetes. Patients with HIP were older (28 years vs. 26 years, p=0.027), had previous tuberculosis (TB) contact (24% vs. 6.5%, p=0.003) and had a bigger hip circumference (107.8 (±10.4) vs. 103.3 (±9.7) cm, p = 0.032). However only previous TB contact was predictive of HIP (odds ratio: 4.4, 95% CI: 1.2-14.0; p=0.022). Using HbA1c as a reference variable, we derived an optimum RBS cutoff of 4.75 mmol/L as predictive of HIP with a sensitivity and specificity of 90.7% and 56.4% (area under the curve = 0.75 (95% CI: 0.70-0.80, p<0.001)), respectively. Conclusions: HIP is common among young Ugandan women, the majority of whom are without identifiable risk factors.en_US
dc.identifier.citationBongomin, F., Kyazze, A. P., Ninsiima, S., Olum, R., Nattabi, G., Nabakka, W., ... & Andia-Biraro, I. (2020). Hyperglycemia in pregnancy diagnosed using glycated hemoglobin (HbA 1c) in Uganda: a preliminary cross-sectional report. Emerald Open Research, 2(70), 70. https://doi.org/10.35241/emeraldopenres.14014.1en_US
dc.identifier.urihttps://doi.org/10.35241/emeraldopenres.14014.1
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7116
dc.language.isoenen_US
dc.publisherEmerald Open Researchen_US
dc.subjectHyperglycemia in pregnancyen_US
dc.subjectPrediabetesen_US
dc.subjectHemoglobin A1cen_US
dc.titleHyperglycemia in pregnancy diagnosed using glycated hemoglobin (HbA1c) in Uganda: a preliminary cross-sectional report [version 1; peer review: 1 approved]en_US
dc.typeArticleen_US
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