Effects of Maternal and Infant Co-infections, and of Maternal Immunization, on the Infant Response to BCG and Tetanus Immunization

Simple item page
dc.contributor.authorKizzaa, Moses
dc.contributor.authorElliott, Alison M.
dc.contributor.authorMawa, Patrice A.
dc.contributor.authorWebb, Emily L.
dc.contributor.authorNampijja, Margaret
dc.contributor.authorLyadd, Nancy
dc.contributor.authorBukusuba, Joseph
dc.contributor.authorKizzaa, Moses
dc.contributor.authorNamujju, Proscovia B.
dc.contributor.authorNabulime, Juliet
dc.contributor.authorNdibazza, Juliet
dc.contributor.authorMuwanga, Moses
dc.contributor.authorWhitworth, James A. G.
dc.date.accessioned2022-01-30T10:24:28Z
dc.date.available2022-01-30T10:24:28Z
dc.date.issued2010
dc.description.abstractSome vaccines show poor efficacy in tropical countries. Within a birth cohort in Uganda, we investigated factors that might influence responses to BCG and tetanus immunisation. Whole blood assay responses to crude culture filtrate proteins of Mycobacterium tuberculosis (cCFP)) and tetanus toxoid (TT) were examined among 1506 and 1433 one-year-olds, respectively. Maternal Mansonella perstans infection was associated with higher interleukin (IL)-10 responses to both immunogens but no reduction in gamma interferon (IFN- ), IL-5 and IL-13 responses; other maternal helminth infections showed little effect. Tetanus immunization during pregnancy was associated with higher infant responses to TT; maternal BCG scar (from past immunization) with lower infant IL-5 and IL-13 responses to cCFP. IFN- , IL-5 and IL-13 to TT were reduced in HIV-exposed-uninfected infants; infant malaria and HIV were associated with lower IFN- , IL-5 and IL-13 responses to both immunogens. We conclude that maternal helminth infections are unlikely to explain poor vaccine efficacy in the tropics. Effects of maternal immunization on infant responses to vaccines should be explored. Prevention of infant malaria and HIV could contribute to effectiveness of immunization programmes.en_US
dc.identifier.citationElliott, A. M., Mawa, P. A., Webb, E. L., Nampijja, M., Lyadda, N., Bukusuba, J., ... & Whitworth, J. A. (2010). Effects of maternal and infant co-infections, and of maternal immunization, on the infant response to BCG and tetanus immunization. Vaccine, 29(2), 247-255. doi:10.1016/j.vaccine.2010.10.047en_US
dc.identifier.otherVaccine
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1619
dc.language.isoenen_US
dc.publisherVaccineen_US
dc.subjectBCGen_US
dc.subjectTetanusen_US
dc.subjectImmunisationen_US
dc.titleEffects of Maternal and Infant Co-infections, and of Maternal Immunization, on the Infant Response to BCG and Tetanus Immunizationen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Effects of maternal and infant co-infections, and of maternal immunisation, on.pdf
Size:
545.62 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences