A hospital-based birth defects surveillance system in Kampala, Uganda

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dc.contributor.authorMumpe-Mwanja, Daniel
dc.contributor.authorBarlow-Mosha, Linda
dc.contributor.authorWilliamson, Dhelia
dc.contributor.authorValencia, Diana
dc.contributor.authorSerunjogi, Robert
dc.contributor.authorKakande, Ayoub
dc.contributor.authorNamale-Matovu, Joyce
dc.contributor.authorNankunda, Jolly
dc.contributor.authorBirabwa-Male, Doreen
dc.contributor.authorOkwero, Margaret Achom
dc.contributor.authorNsungwa-Sabiiti, Jesca
dc.contributor.authorMusoke, Philippa
dc.date.accessioned2021-12-15T07:34:36Z
dc.date.available2021-12-15T07:34:36Z
dc.date.issued2019
dc.description.abstractBackground: In 2010, the World Health Assembly passed a resolution calling upon countries to prevent birth defects where possible. Though birth defects surveillance programs are an important source of information to guide implementation and evaluation of preventive interventions, many countries that shoulder the largest burden of birth defects do not have surveillance programs. This paper shares the results of a hospital-based birth defects surveillance program in Uganda which, can be adopted by similar resource-limited countries. Methods: All informative births, including live births, stillbirths and spontaneous abortions; regardless of gestational age, delivered at four selected hospitals in Kampala from August 2015 to December 2017 were examined for birth defects. Demographic data were obtained by midwives through maternal interviews and review of hospital patient notes and entered in an electronic data collection tool. Identified birth defects were confirmed through bedside examination by a physician and review of photographs and a narrative description by a birth defects expert. Informative births (live, still and spontaneous abortions) with a confirmed birth defect were included in the numerator, while the total informative births (live, still and spontaneous abortions) were included in the denominator to estimate the prevalence of birth defects per 10,000 births. Results: The overall prevalence of birth defects was 66.2/10,000 births (95% CI 60.5–72.5). The most prevalent birth defects (per 10,000 births) were: Hypospadias, 23.4/10,000 (95% CI 18.9–28.9); Talipes equinovarus, 14.0/10,000 (95% CI11.5–17.1) and Neural tube defects, 10.3/10,000 (95% CI 8.2–13.0). The least prevalent were: Microcephaly, 1.6/10,000 (95% CI 0.9–2.8); Microtia and Anotia, 1.6/10,000 (95% CI 0.9–2.8) and Imperforate anus, 2.0/10,000 (95% CI 1.2–3.4). Conclusion: A hospital-based surveillance project with active case ascertainment can generate reliable epidemiologic data about birth defects prevalence and can inform prevention policies and service provision needs in low and middle income countries.en_US
dc.identifier.citationMumpe-Mwanja, D., Barlow-Mosha, L., Williamson, D., Valencia, D., Serunjogi, R., Kakande, A., ... & Musoke, P. (2019). A hospital-based birth defects surveillance system in Kampala, Uganda. BMC pregnancy and childbirth, 19(1), 1-9.https://doi.org/10.1186/s12884-019-2542-xen_US
dc.identifier.urihttps://doi.org/10.1186/s12884-019-2542-x
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/537
dc.language.isoenen_US
dc.publisherBMC pregnancy and childbirthen_US
dc.subjectBirth defectsen_US
dc.subjectCongenital anomaliesen_US
dc.subjectBirth prevalenceen_US
dc.subjectHospital-based surveillanceen_US
dc.subjectUgandaen_US
dc.titleA hospital-based birth defects surveillance system in Kampala, Ugandaen_US
dc.typeArticleen_US
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