Associations Between Maternal Helminth and Malaria Infections in Pregnancy and Clinical Malaria in the Offspring: A Birth Cohort in Entebbe, Uganda

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dc.contributor.authorNdibazza, Juliet
dc.contributor.authorWebb, Emily L.
dc.contributor.authorLule, Swaib
dc.contributor.authorMpairwe, Harriet
dc.contributor.authorAkello, Miriam
dc.contributor.authorOduru, Gloria
dc.contributor.authorKizza, Moses
dc.contributor.authorAkurut, Helen
dc.contributor.authorMuhangi, Lawrence
dc.contributor.authorMagnussen, Pascal
dc.contributor.authorVennervald, Birggite
dc.contributor.authorElliott, Alison
dc.date.accessioned2021-12-14T13:30:22Z
dc.date.available2021-12-14T13:30:22Z
dc.date.issued2013
dc.description.abstractBackground. Helminth and malaria coinfections are common in the tropics. We investigated the hypothesis that prenatal exposure to these parasites might influence susceptibility to malaria in childhood. Methods. In a birth cohort of 2345 mother–child pairs in Uganda, maternal helminth and malaria infection status was determined during pregnancy, and childhood malaria episodes were recorded from birth to age 5 years. We examined associations between maternal infections and malaria in the offspring. Results. Common maternal infections were hookworm (45%), Mansonella perstans (21%), Schistosoma mansoni (18%), and Plasmodium falciparum (11%). At age 5 years, 69% of the children were still under follow-up. The incidence of malaria was 34 episodes per 100 child-years, and the mean prevalence of asymptomatic malaria at annual visits was 5.4%. Maternal hookworm and M. perstans infections were associated with an increased rate of childhood clinical malaria (adjusted hazard ratio [aHR], 1.24, 95% confidence interval [CI], 1.10–1.41; aHR, 1.20, 95% CI, 1.05–1.38, respectively). S. mansoni infection had no consistent association with childhood malaria. Conclusions. This is the first report of an association between helminth infections in pregnancy and malaria in the offspring and indicates that helminth infections in pregnancy may increase the burden of childhood malaria morbidity.en_US
dc.identifier.citationNdibazza, J., Webb, E. L., Lule, S., Mpairwe, H., Akello, M., Oduru, G., ... & Elliott, A. (2013). Associations between maternal helminth and malaria infections in pregnancy and clinical malaria in the offspring: a birth cohort in entebbe, Uganda. The Journal of infectious diseases, 208(12), 2007-2016.DOI: 10.1093/infdis/jit397en_US
dc.identifier.other10.1093/infdis/jit397
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/509
dc.language.isoenen_US
dc.publisherThe Journal of infectious diseasesen_US
dc.subjectMalariaen_US
dc.subjectHelminthsen_US
dc.subjectCoinfectionsen_US
dc.subjectPregnancyen_US
dc.subjectChildhooden_US
dc.titleAssociations Between Maternal Helminth and Malaria Infections in Pregnancy and Clinical Malaria in the Offspring: A Birth Cohort in Entebbe, Ugandaen_US
dc.typeArticleen_US
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