In vivo antidiarrheal activity of the ethanolic leaf extract of Catharanthus roseus Linn. (Apocyanaceae) in Wistar rats

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dc.contributor.authorKyakulaga, A. Hassan
dc.contributor.authorAlinda, T. Brenda
dc.contributor.authorVudriko, Patrick
dc.contributor.authorOgwang Engeu, Patrick
dc.date.accessioned2021-12-15T09:15:51Z
dc.date.available2021-12-15T09:15:51Z
dc.date.issued2011
dc.description.abstractCatharanthus roseus is a medicinal plant with various pharmacological properties. In this study, we investigated the in vivo antidiarrheal activity of C. roseus ethanolic leaf extract in Wistar rats. Castor oil was used to induce experimental diarrhea in rats pretreated with extracts administered at 200 and 500 mg/kg to determine antidiarrheal effect. Loperamide and atropine sulphate were used as standard drugs in the two experiments. Preliminary phytochemical screening of the extract revealed the presence of alkaloids, tannins, triterpenes, flavonoids and saponins. The antidiarrheal effect of ethanolic extract of C. roseus revealed a dose dependant inhibition of castor oil induced diarrhea at doses of 200 and 500 mg/kg. On comparison of the extract with the negative control, there was a significant difference at 200 mg/kg (P < 0.05) and a more significant difference at 500 mg/kg (P < 0.001). Test extract’s effect was further evaluated on intestinal transit and it exhibited dose dependant inhibition of transit motility of charcoal meal. The results indicated that the ethanol extract of C. roseus possesses significant antidiarrheal effect and corroborate the use of this herbal remedy as non-specific treatment for diarrhea in folk medicine.en_US
dc.identifier.citationHassan, K. A., Brenda, A. T., Patrick, V., & Patrick, O. E. (2011). In vivo antidiarrheal activity of the ethanolic leaf extract of Catharanthus roseus Linn.(Apocyanaceae) in Wistar rats. African Journal of Pharmacy and Pharmacology, 5(15), 1797-1800.doi: 10.5897/AJPP11.505en_US
dc.identifier.issn1996-0816
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/554
dc.language.isoenen_US
dc.publisherAfrican Journal of Pharmacy and Pharmacologyen_US
dc.subjectCatharansu roseusen_US
dc.subjectantidiarrhealen_US
dc.subjectethanolicen_US
dc.subjectphytochemicalen_US
dc.titleIn vivo antidiarrheal activity of the ethanolic leaf extract of Catharanthus roseus Linn. (Apocyanaceae) in Wistar ratsen_US
dc.typeArticleen_US
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