Understanding asthma phenotypes: the World Asthma Phenotypes (WASP) international collaboration

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dc.contributor.authorPembrey, Lucy
dc.contributor.authorBarreto, Mauricio L.
dc.contributor.authorDouwes, Jeroen
dc.contributor.authorCooper, Philip
dc.contributor.authorHenderson, John
dc.contributor.authorMpairwe, Harriet
dc.contributor.authorArdura-Garcia, Cristina
dc.contributor.authorChico, Martha
dc.contributor.authorBrooks, Collin
dc.contributor.authorCruz, Alvaro A.
dc.contributor.authorElliott, Alison M.
dc.contributor.authorFigueiredo, Camila A.
dc.contributor.authorLangan, Sinéad M.
dc.contributor.authorNassanga, Beatrice
dc.contributor.authorRing, Susan
dc.contributor.authorRodrigues, Laura C.
dc.contributor.authorPearce, Neil
dc.date.accessioned2021-12-21T08:41:20Z
dc.date.available2021-12-21T08:41:20Z
dc.date.issued2018
dc.description.abstractThe World Asthma Phenotypes (WASP) study started in 2016 and has been conducted in five centres, in the UK, New Zealand, Brazil, Ecuador and Uganda. The objectives of this study are to combine detailed biomarker and clinical information in order to 1) better understand and characterise asthma phenotypes in high-income countries (HICs) and low and middle-income countries (LMICs), and in high and low prevalence centres; 2) compare phenotype characteristics, including clinical severity; 3) assess the risk factors for each phenotype; and 4) assess how the distribution of phenotypes differs between high prevalence and low prevalence centres. Here we present the rationale and protocol for the WASP study to enable other centres around the world to carry out similar analyses using a standardised protocol. Large collaborative and integrative studies like this are essential to further our understanding of asthma phenotypes. The findings of this study will help elucidate the aetiological mechanisms of asthma and might potentially identify new causes and guide the development of new treatments, thereby enabling better management and prevention of asthma in both HICs and LMICs.en_US
dc.identifier.citationPembrey, L., Barreto, M. L., Douwes, J., Cooper, P., Henderson, J., Mpairwe, H., ... & Pearce, N. (2018). Understanding asthma phenotypes: the World Asthma Phenotypes (WASP) international collaboration. ERJ open research, 4(3). DOI:10.1183/23120541.00013-2018en_US
dc.identifier.uri10.1183/23120541.00013-2018
dc.identifier.uri10.1183/23120541.00013-2018
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/883
dc.language.isoenen_US
dc.publisherERJ open research,en_US
dc.relation.ispartofseriesERJ open research,;
dc.subjectAsthma phenotypesen_US
dc.subjectWorld Asthma Phenotypesen_US
dc.subjectinternational collaborationen_US
dc.titleUnderstanding asthma phenotypes: the World Asthma Phenotypes (WASP) international collaborationen_US
dc.typeArticleen_US
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