Is it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?

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dc.contributor.authorCastelnuovo, Barbara
dc.contributor.authorNanyonjo, Agnes
dc.contributor.authorKamya, Moses
dc.contributor.authorOcama, Ponsiano
dc.date.accessioned2022-04-30T21:29:37Z
dc.date.available2022-04-30T21:29:37Z
dc.date.issued2008
dc.description.abstractIn resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative. Case report: We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda. Discussion: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse. Therefore we recommend close follow up for patients that are switched from stavudine to zidovudine and, in case lactate measurement is not possible, free programs should provide safer drugs such as abacavir and tenofovir for patients that develop hyperlactatemia.en_US
dc.identifier.citationCastelnuovo, B., Nanyonjo, A., Kamya, M., & Ocama, P. (2008). Case Report: Is it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?. African Health Sciences, 8(2).en_US
dc.identifier.urihttps://www.ajol.info/index.php/ahs/article/view/7062
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3083
dc.language.isoenen_US
dc.publisherAfrican Health Sciencesen_US
dc.subjectStavudineen_US
dc.subjectZidovudineen_US
dc.subjectHyperlactatemiaen_US
dc.titleIs it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?en_US
dc.typeArticleen_US
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