Induction of the Antigen 85 Complex of Mycobacterium tuberculosis in Sputum: A Determinant of Outcome in Pulmonary Tuberculosis Treatment

Simple item page
dc.contributor.authorWallis, Robert S.
dc.contributor.authorPerkins, Mark
dc.contributor.authorPhillips, Manijeh
dc.contributor.authorJoloba, Moses
dc.contributor.authorDemchuk, Barbara
dc.contributor.authorNamale, Alice
dc.contributor.authorJohnson, John L.
dc.contributor.authorWilliams, Donna
dc.contributor.authorWolski, Kathy
dc.contributor.authorDietze, Reynaldo
dc.contributor.authorMugerwa, Roy D.
dc.contributor.authorEisenach, Kathleen
dc.contributor.authorEllner, Jerrold J.
dc.date.accessioned2021-12-18T07:03:52Z
dc.date.available2021-12-18T07:03:52Z
dc.date.issued1998
dc.description.abstractSputum quantitative culture, acid-fast smear, days-to-positive by BACTEC, and Mycobacterium tuberculosis antigen 85 complex were monitored during therapy in 42 patients with pulmonary tuberculosis (TB). By BACTEC, 4 patients were persistently positive on days 90–180, and treatment ultimately failed in 2 of these. Antigen 85 expression increased in subjects in whom disease persisted (persisters) from days 0 to 14 when the difference between persisters and nonpersisters was statistically significant (P .002). Only antigen 85 complex values at day 14 suggested TB persistence at or after day 90. All subjects with day 14 antigen 85 complex values 60 pg/mL responded rapidly to treatment and were cured. Of those with values 60 pg/mL, in 33% TB persisted at or after day 90 and treatment failed in 17%. Biologic factors expressed early in therapy, not related to compliance or resistance, may exert a substantial influence on outcome. The antigen 85 complex is critical in cell wall biosynthesis and is induced by isoniazid in vitro. Its induction may represent an adaptive transition to a persistent state during therapyen_US
dc.identifier.citationWallis, RS, Perkins, M., Phillips, M., Joloba, M., Demchuk, B., Namale, A., ... & Ellner, JJ (1998). Induction of the antigen 85 complex of Mycobacterium tuberculosis in sputum: a determinant of outcome in pulmonary tuberculosis treatment. The Journal of infectious diseases , 178 (4), 1115-1121.en_US
dc.identifier.urihttps://academic.oup.com/jid/article-abstract/178/4/1115/837925
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/786
dc.language.isoenen_US
dc.publisherThe Journal of infectious diseasesen_US
dc.subjectAntigenen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectSputumen_US
dc.subjectTuberculosisen_US
dc.subjectTreatmenten_US
dc.titleInduction of the Antigen 85 Complex of Mycobacterium tuberculosis in Sputum: A Determinant of Outcome in Pulmonary Tuberculosis Treatmenten_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Induction of the Antigen 85 Complex of Mycobacterium tuberculosis in Sputum A Determinant of Outcome in Pulmonary Tuberculosis Treatment.pdf
Size:
240.83 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences