Prevalence, risk factors and treatment outcomes of isoniazid resistant TB in Bulawayo city, Zimbabwe: A cohort study

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dc.contributor.authorManyame-Murwira, Barbara
dc.contributor.authorTakarinda, Kudakwashe Collin
dc.contributor.authorThekkur, Pruthu
dc.contributor.authorPayera, Bright
dc.contributor.authorMutunzi, Herbert
dc.contributor.authorSimbi, Raiva
dc.contributor.authorSiziba, Nicholas
dc.contributor.authorSibanda, Edwin
dc.contributor.authorBanana, Catherine
dc.contributor.authorMuleya, Norbert
dc.contributor.authorMakombe, Evidence
dc.contributor.authorJongwe, Paula Littia
dc.contributor.authorBhebhe, Regina
dc.contributor.authorMangwanya, Douglas
dc.contributor.authorDzangare, Janet
dc.contributor.authorMudzengerere, Fungai H
dc.contributor.authorTimire, Collins
dc.contributor.authorWekiya, Enock
dc.contributor.authorSandy, Charles
dc.date.accessioned2021-12-10T18:25:34Z
dc.date.available2021-12-10T18:25:34Z
dc.date.issued2020
dc.description.abstractThe isoniazid-resistant TB poses a threat to TB control efforts. Zimbabwe, one of the high TB burden countries, has not explored the burden of isoniazid resistant TB. Hence among all bacteriologically-confirmed TB patients diagnosed in Bulawayo City during March 2017 and December 2018, we aimed to assess the proportion with isoniazid resistant TB and associated factors. Also, we aimed to describe the TB treatment outcomes. Methodology: A cohort study involving routinely collected data by the National TB Reference Laboratory (NTBRL) in Bulawayo City and National TB programme of Zimbabwe. The percentage with 95% confidence interval (CI) was used to express the proportion with isoniazid-resistant TB. The modified Poisson regression was used to assess the association of demographic and clinical characteristics with isoniazid mono-resistant TB. Results: Of 2160 bacteriologically-confirmed TB patients, 1612 (74.6%) had their sputum received at the NTBRL and 743 (46.1%) had culture growth. Among those with culture growth, 34 (4.6%, 95% CI: 3.5-6.7) had isoniazid mono-resistant TB, 25 (3.3%, 95% CI: 2.2-4.9) had MDR-TB. Thus, 59 (7.9%, 95% CI: 6.1-10.1) had isoniazid-resistant TB. Children < 15 years had a higher prevalence of isoniazid mono-resistant TB (aPR= 3.93; 95% CI: 1.24-12.45). Among those with rifampicin sensitive TB, patients with isoniazid-sensitive TB had higher favourable treatment outcomes compared to those with isoniazid-resistant TB (86.3% versus 75.5%, p = 0.039). Conclusions: The prevalence of isoniazid-resistant TB was low compared to neighbouring countries with high burden of TB-HIV. However, Zimbabwe should consider reviewing treatment guidelines for isoniazid mono-resistant TB due to the observed poor treatment outcomes.en_US
dc.identifier.citationManyame-Murwira, B., Takarinda, K. C., Thekkur, P., Payera, B., Mutunzi, H., Simbi, R., ... & Sandy, C. (2020). Prevalence, risk factors and treatment outcomes of isoniazid resistant TB in Bulawayo city, Zimbabwe: A cohort study. The Journal of Infection in Developing Countries, 14(08), 893-900. doi:10.3855/jidc.12319en_US
dc.identifier.other10.3855/jidc.12319
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/269
dc.language.isoenen_US
dc.publisherThe Journal of Infection in Developing Countriesen_US
dc.subjectTuberculosisen_US
dc.subjectIsoniazid mono-resistanceen_US
dc.subjectIPTen_US
dc.subjectOperational Researchen_US
dc.subjectSORT-ITen_US
dc.titlePrevalence, risk factors and treatment outcomes of isoniazid resistant TB in Bulawayo city, Zimbabwe: A cohort studyen_US
dc.typeArticleen_US
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