Phosphatidylethanol confirmed alcohol use among ART-naïve HIV-infected persons who denied consumption in rural Uganda

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dc.contributor.authorMuyindike, Winnie R.
dc.contributor.authorLloyd-Travaglini, Christine
dc.contributor.authorFatch, Robin
dc.contributor.authorEmenyonu, Nneka I.
dc.contributor.authorAdong, Julian
dc.contributor.authorNgabirano, Christine
dc.contributor.authorCheng, Debbie M.
dc.contributor.authorWinter, Michael R.
dc.contributor.authorSamet, Jeffrey H.
dc.contributor.authorHahn, Judith A.
dc.date.accessioned2022-01-30T20:25:04Z
dc.date.available2022-01-30T20:25:04Z
dc.date.issued2017
dc.description.abstractUnder-reporting of alcohol use by HIV-infected patients could adversely impact clinical care. This study examined factors associated with under-reporting of alcohol consumption by patients who denied alcohol use in clinical and research settings using an alcohol biomarker. We enrolled ARTnaïve, HIV-infected adults at Mbarara Hospital HIV clinic in Uganda. We conducted baseline interviews on alcohol use, demographics, Spirituality and Religiosity Index (SRI), health and functional status; and tested for breath alcohol content and collected blood for phosphatidylethanol (PEth), a sensitive and specific biomarker of alcohol use. We determined PEth status among participants who denied alcohol consumption to clinic counselors (Group 1, n = 104), and those who denied alcohol use on their research interview (Group 2, n = 198). A positive PEth was defined as ≥8 ng/ml. Multiple logistic regression models were used to examine whether testing PEth-positive varied by demographics, literacy, spirituality, socially desirable reporting and physical health status. Results showed that, among the 104 participants in Group 1, 28.8% were PEth-positive. The odds of being PEth-positive were higher for those reporting prior unhealthy drinking (adjusted odds ratio (AOR): 4.7, 95% confidence interval (CI): 1.8, 12.5). No other factors were statistically significant. Among the 198 participants in Group 2, 13.1% were PEth-positive. The odds of being PEth-positive were higher for those reporting past unhealthy drinking (AOR: 4.6, 95% CI: 1.8, 12.2), the Catholics (AOR: 3.8, 95% CI: 1.3, 11.0) compared to Protestants and lower for the literate participants (AOR: 0.3, 95% CI: 0.1, 0.8). We concluded that under-reporting of alcohol use to HIV clinic staff was substantial, but it was lower in a research setting that conducted testing for breath alcohol and PEth. A report of past unhealthy drinking may highlight current alcohol use among deniers. Strategies to improve alcohol self-report are needed within HIV care settings in Uganda.en_US
dc.identifier.citationWinnie R. Muyindike, Christine Lloyd-Travaglini, Robin Fatch, Nneka I. Emenyonu, Julian Adong, Christine Ngabirano, Debbie M. Cheng, Michael R. Winter, Jeffrey H. Samet & Judith A. Hahn (2017): Phosphatidylethanol confirmed alcohol use among ARTnaïve HIV-infected persons who denied consumption in rural Uganda, AIDS Care, DOI: 10.1080/09540121.2017.1290209en_US
dc.identifier.urihttp://dx.doi.org/10.1080/09540121.2017.1290209
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1638
dc.language.isoenen_US
dc.publisherAIDS Careen_US
dc.subjectAlcohol consumptionen_US
dc.subjectHIVen_US
dc.subjectUnder-reporten_US
dc.subjectPhosphatidylethanolen_US
dc.subjectUgandaen_US
dc.titlePhosphatidylethanol confirmed alcohol use among ART-naïve HIV-infected persons who denied consumption in rural Ugandaen_US
dc.typeArticleen_US
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