Reliability and validity of the center for epidemiologic studies-depression scaleinscreening for depression among HIV-infected and -uninfected pregnant women attending antenatal services in northern Uganda: a cross-sectional study

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dc.contributor.authorNatamba, Barnabas K.
dc.contributor.authorAchan, Jane
dc.contributor.authorArbach, Angela
dc.contributor.authorOyok, Thomas O.
dc.contributor.authorGhosh, Shibani
dc.contributor.authorMehta, Saurabh
dc.contributor.authorStoltzfus, Rebecca J.
dc.contributor.authorGriffiths, Jeffrey K.
dc.contributor.authorYoung, Sera L.
dc.date.accessioned2021-12-11T09:58:05Z
dc.date.available2021-12-11T09:58:05Z
dc.date.issued2014
dc.description.abstractBackground: There are limited data on the prevalence and approaches to screening for depression among pregnant women living in resource poor settings with high HIV burden. Methods: We studied the reliability and accuracy of the Center for Epidemiologic Studies Depression (CES-D) scale in 123 (36 HIV-infected and 87 -uninfected) pregnant women receiving antenatal care at Gulu Regional Referral Hospital, Uganda. CES-D scores were compared to results from the psychiatrist-administered Mini-International Neuropsychiatric Interview (MINI) for current major depressive disorder (MDD), a “gold standard” for assessingdepression. We employed measures of internal consistency (Cronbach’s alpha), and criterion validity [Area Underthe Receiver Operating Characteristic Curve (AUROC), sensitivity (Se), specificity (Sp), and positive predictive value(PPV)] to evaluate the reliability and validity of the CES-D scale. Results: 35.8% of respondents were currently experiencing an MDD, as defined from outputs of the MINI-depression module. The CES-D had high internal consistency (Cronbach’s alpha = 0.92) and good discriminatory ability in detecting MINI-defined current MDDs (AUROC = 0.82). The optimum CES-D cutoff score for the identification of probable MDD was between 16 and 17. A CES-D cutoff score of 17, corresponding to Se, Sp, and PPV values of 72.7%, 78.5%, and 76.5%, is proposed for adoption in this population and performs well for HIV-infected and -uninfected women. Afteradjusting for baseline differences between the HIV subgroups (maternal age and marital status), HIV-infectedpregnant women scored 6.2 points higher on the CES-D than HIV-uninfected women (p = 0.032).Conclusions: The CES-D is a suitable instrument for screening for probable major depression among pregnant womenof mixed HIV status attending antenatal services in northern Uganda.en_US
dc.identifier.citationNatamba et al.: Reliability and validity of the center for epidemiologic studies-depression scale in screening for depression among HIV-infected and -uninfected pregnant women attending antenatal services in northern Uganda: a cross-sectional study. BMC Psychiatry 2014 14:303. doi:10.1186/s12888-014-0303-yen_US
dc.identifier.other10.1186/s12888-014-0303-y
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/297
dc.language.isoenen_US
dc.publisherBMC Psychiatryen_US
dc.subjectPregnancyen_US
dc.subjectMajor depressionen_US
dc.subjectPrenatal depressionen_US
dc.subjectUgandaen_US
dc.subjectAfricaen_US
dc.subjectScreeningen_US
dc.titleReliability and validity of the center for epidemiologic studies-depression scaleinscreening for depression among HIV-infected and -uninfected pregnant women attending antenatal services in northern Uganda: a cross-sectional studyen_US
dc.typeArticleen_US
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