Quinine monotherapy for treating uncomplicated malaria in the era of artemisinin-based combination therapy: an appropriate public health policy?

Simple item page
dc.contributor.authorYeka, Adoke
dc.contributor.authorAchan, Jane
dc.contributor.authorD’Alessandro, Umberto
dc.contributor.authorTalisuna, Ambrose O.
dc.date.accessioned2021-12-11T09:14:04Z
dc.date.available2021-12-11T09:14:04Z
dc.date.issued2009
dc.description.abstractSeveral African countries that have adopted artemisinin-based combination therapy (ACT) as fi rst-line treatment of uncomplicated Plasmodium falciparum malaria also use quinine monotherapy as second-line therapy. This policy goes against WHO recommendations for combination therapy and could be considered an inappropriate public health policy. Adherence to a 7-day quinine treatment schedule is likely to be poor and may increase the risk of selecting resistant parasites. Furthermore, because quinine has limited post-treatment prophylaxis, it will not prevent, in areas of intense transmission, recurrent malaria infections, which can lead to additional morbidity, including anaemia. Therefore, ACTs and not quinine should be used as second-line treatment, because these are well tolerated, highly effi cacious, and have the advantage of reducing gametocyte carriage and consequently malaria transmissibility, particularly in areas of less intense transmission.en_US
dc.identifier.citationYeka, A., Achan, J., D'Alessandro, U., & Talisuna, A. O. (2009). Quinine monotherapy for treating uncomplicated malaria in the era of artemisinin-based combination therapy: an appropriate public health policy?. The Lancet infectious diseases, 9(7), 448-452.en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/291
dc.language.isoenen_US
dc.publisherThe Lancet infectious diseasesen_US
dc.subjectQuinine monotherapyen_US
dc.subjectMalariaen_US
dc.subjectTreatingen_US
dc.titleQuinine monotherapy for treating uncomplicated malaria in the era of artemisinin-based combination therapy: an appropriate public health policy?en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Quinine monotherapy for treating uncomplicated malaria in.pdf
Size:
115.45 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences