Antiplasmodial Compounds from Millettia Dura

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dc.contributor.authorBuyinza, Daniel
dc.contributor.authorDerese, Solomon
dc.contributor.authorNdakala, Albert
dc.date.accessioned2023-01-26T15:32:17Z
dc.date.available2023-01-26T15:32:17Z
dc.date.issued2022
dc.description.abstractMalaria still poses a big challenge to the health care of many tropical countries. The plasmodium resistance to the conventional drugs is the major hitch in its treatment. Higher plants have produced single line antimalarials and given important lead molecules. On this basis, flavonoids isolated from millettia dura by chromatographic techniques were screened againest W2 and D6 strains of plasmoduim falcipalum. Both, the crude and pure compounds tested showed mild activities against the test organisms. The crude extract of the stem bark had the highest respective activity of 63.7±8.6 and 46.1±4.5 μg/ml against W2 and D6. Of the pure compounds, milletosin was active towards both W2 and D6 with a respective IC50s of 87.9±8.9 and 66.70±30.3 μg/ml. Synergistic effect might have contributed to the relative high activity of the crude than the pure compounds. Basing on the structure activity relationship of the tested compounds, suitable structural modification could be ideal to enhance the antiplasmodial activity.en_US
dc.identifier.citationBuyinza, D., Derese, S., & Ndakala, A. (2022). Antiplasmodial compounds from Millettia dura. Kabale University Interdisciplinary Research Journal, 1(3), 22-30.en_US
dc.identifier.issn2790-1394
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7275
dc.language.isoenen_US
dc.publisherKabale University Interdisciplinary Research Journalen_US
dc.subjectMalaria, Antiplasmodial, Millettia dura, Higher-plants and antimalarial-resistanceen_US
dc.titleAntiplasmodial Compounds from Millettia Duraen_US
dc.typeArticleen_US
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