Distribution of HLA-B alleles in a Ugandan HIV-infected adult population: NORA pharmacogenetic substudy of DART

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dc.contributor.authorMunderi, Paula
dc.contributor.authorSnowden, Wendy B.
dc.contributor.authorKityo, Cissy
dc.contributor.authorKabuye, Geoffrey
dc.contributor.authorThoofer, Navdeep K.
dc.contributor.authorSsali, Francis
dc.contributor.authorGilks, Charles F.
dc.contributor.authorHughes, Arlene R.
dc.date.accessioned2023-03-30T11:48:27Z
dc.date.available2023-03-30T11:48:27Z
dc.date.issued2011
dc.description.abstractTo determine the frequencies of HLA-B alleles in Ugandan patients in the NORA substudy of the DART trial and to compare HLA-B allele frequencies in those with and without clinically diagnosed hypersensitivity reaction (HSR). DNA-based HLA-B genotyping was used to determine HLA alleles in 247 participants who received abacavir, including all six participants (‘cases’) with clinically diagnosed abacavir HSR. The incidence of clinical abacavir HSR in this double-blinded study was 2.0% (6/300) in the abacavir group. As HLA-B*5701 was absent throughout the entire cohort, including the six HSR ‘cases’, an association could not be established between HLA-B*5701 and clinically diagnosed abacavir HSR. No other HLA-B*57 alleles were present among the six ‘cases’. HLA-B*5703 was the most frequent HLA-B*57 allele among the abacavir-tolerant participants. The rate of clinical HSR was low, which may reflect the expected 2–3% clinical false-positive rate seen in previous double-blind randomized studies. The presumption that these cases may be false-positive abacavir HSR is supported by the fact that no HLA-B*5701 alleles were found in the abacavir group. Implementation of prospective HLA-B*5701 screening must be based on benefit/risk considerations within local practice. Clinical risk management remains paramount.en_US
dc.identifier.citationMunderi, P., Snowden, W. B., Walker, A. S., Kityo, C., Mosteller, M., Kabuye, G., ... & DART Trial Team. (2011). Distribution of HLA‐B alleles in a Ugandan HIV‐infected adult population: NORA pharmacogenetic substudy of DART. Tropical medicine & international health, 16(2), 200-204.https://doi.org/10.1111/j.1365-3156.2010.02688.xen_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8341
dc.language.isoenen_US
dc.publisherTropical medicine & international healthen_US
dc.subjectAfrican Continental Ancestry Groupen_US
dc.subjectAIDSen_US
dc.subjectPharmacogeneticsen_US
dc.subjectDrug hypersensitivityen_US
dc.subjectHLA-B*5701en_US
dc.titleDistribution of HLA-B alleles in a Ugandan HIV-infected adult population: NORA pharmacogenetic substudy of DARTen_US
dc.typeArticleen_US
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