Transmitted Antiretroviral Drug Resistance Surveillance among Newly HIV Type 1-Diagnosed Women Attending an Antenatal Clinic in Entebbe, Uganda

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dc.contributor.authorNdembi, N.
dc.contributor.authorLyagoba, F.
dc.contributor.authorNanteza, B.
dc.contributor.authorKushemererwa, G.
dc.contributor.authorSerwanga, J.
dc.contributor.authorMbidde, E. Katongole
dc.contributor.authorGrosskurth, H.
dc.contributor.authorKaleebu, P.
dc.contributor.authoron behalf of the Uganda HIV Drug Resistance Working Group
dc.date.accessioned2022-01-24T19:29:14Z
dc.date.available2022-01-24T19:29:14Z
dc.date.issued2008
dc.description.abstractTo evaluate transmitted HIV-1 drug resistance and study the natural polymorphism in pol of HIV-1 strains of newly diagnosed women attending an antenatal clinic in Uganda we sequenced the protease and reverse transcriptase genes for 46 HIV-1 strains from the threshold surveillance. Of the 46 sequences analyzed, 48.0% were subtype A1 (n = 22), 39.0% subtype D (n = 18), 2.0% subtype A2 (n = 1), 2.0% subtype C (n = 1), and 9.0% intersubtype recombinant A1/D (n = 4). Overall, many minor mutations were identified in the protease sequences. None of the strains had major associated mutations to any RTI drug or drug class interest after genotyping 37 samples of our cohort. The HIV drug resistance prevalence estimate in Entebbe following the HIVDR-TS methodology is less than 5% as set out by WHO guidelines.en_US
dc.identifier.citationNdembi, N., Lyagoba, F., Nanteza, B., Kushemererwa, G., Serwanga, J., Katongole-Mbidde, E., ... & Uganda HIV Drug Resistance Working Group. (2008). Transmitted antiretroviral drug resistance surveillance among newly HIV type 1-diagnosed women attending an antenatal clinic in Entebbe, Uganda. AIDS research and human retroviruses, 24(6), 889-895.https://doi.org/10.1089/aid.2007.0317en_US
dc.identifier.issn889-895
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1517
dc.language.isoenen_US
dc.publisherAIDS research and human retrovirusesen_US
dc.titleTransmitted Antiretroviral Drug Resistance Surveillance among Newly HIV Type 1-Diagnosed Women Attending an Antenatal Clinic in Entebbe, Ugandaen_US
dc.typeArticleen_US
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