Assessment of parasite clearance following treatment of severe malaria with intravenous artesunate in Ugandan children enrolled in a randomized controlled clinical trial
Loading...
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Malaria journal
Abstract
Worldwide, malaria ranks as one of the most important causes of morbidity and mortality with 216 million cases and 445,000 deaths in 2016 alone, 90% of cases and deaths occur in Africa and 80% in sub-Saharan Africa Uganda is one of the heavy malaria burden countries where Plasmodium falciparum, which causes the most severe form of disease is the most prevalent [1]. Malaria is transmitted by the female Anopheles mosquito which injects sporozoites into the human host. Sporozoites
undergo pre-erythrocytic and erythrocytic stages of multiplication causing erythrocyte rupture with release of merozoites and pro-inflammatory cytokines into circulation, which are responsible for the symptoms. Patients seek medical attention when they begin to experience symptoms of malaria.
Description
Keywords
Artesunate, ACT, Malaria, Parasite clearance
Citation
Byakika-Kibwika, P., Nyakato, P., Lamorde, M., & Kiragga, A. N. (2018). Assessment of parasite clearance following treatment of severe malaria with intravenous artesunate in Ugandan children enrolled in a randomized controlled clinical trial. Malaria journal, 17(1), 1-6. https://doi.org/10.1186/s12936-018-2552-6