Serosurveillance to Monitor Onchocerciasis Elimination: The Ugandan Experience

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dc.contributor.authorOguttu, David
dc.contributor.authorByamukama, Edson
dc.contributor.authorKatholi, Charles R.
dc.contributor.authorHabomugisha, Peace
dc.contributor.authorNahabwe, Christine
dc.contributor.authorNgabirano, Monica
dc.contributor.authorHassan, Hassan K.
dc.contributor.authorLakwo, Thomson
dc.contributor.authorKatabarwa, Moses
dc.contributor.authorRichards, Frank O.
dc.contributor.authorUnnasch, Thomas R.
dc.date.accessioned2022-01-30T20:47:27Z
dc.date.available2022-01-30T20:47:27Z
dc.date.issued2014
dc.description.abstractUganda is the only African country whose onchocerciasis elimination program uses a two-pronged approach of vector control and mass drug distribution. The Ugandan program relies heavily upon the use of serosurveys of children to monitor progress toward elimination. The program has tested over 39,000 individuals from 11 foci for Onchocerca volvulus exposure, using the Ov16 ELISA test. The data show that the Ov16 ELISA is a useful operational tool to monitor onchocerciasis transmission interruption in Africa at the World Health Organization (WHO) recommended threshold of < 0.1% in children. The Ugandan experience has also resulted in a re-examination of the statistical methods used to estimate the boundary of the upper 95% confidence interval for the WHO prevalence threshold when all samples tested are negative. This has resulted in the development of Bayesian and hypergeometric statistical methods that reduce the number of individuals who must be tested to meet the WHO criterion.en_US
dc.identifier.citationOguttu, D., Byamukama, E., Katholi, C. R., Habomugisha, P., Nahabwe, C., Ngabirano, M., ... & Unnasch, T. R. (2014). Serosurveillance to monitor onchocerciasis elimination: the Ugandan experience. The American journal of tropical medicine and hygiene, 90(2), 339. doi:10.4269/ajtmh.13-0546en_US
dc.identifier.other10.4269/ajtmh.13-0546
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1640
dc.language.isoenen_US
dc.publisherThe American journal of tropical medicine and hygieneen_US
dc.subjectSerosurveillanceen_US
dc.subjectOnchocerciasis Eliminationen_US
dc.subjectUgandan Experienceen_US
dc.titleSerosurveillance to Monitor Onchocerciasis Elimination: The Ugandan Experienceen_US
dc.typeArticleen_US
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