The burden, pattern and factors that contribute to periportal fibrosis in HIV-infected patients in an S. mansoni endemic rural Uganda.

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dc.contributor.authorOcama, Ponsiano
dc.contributor.authorOpio, Kenneth Christopher
dc.contributor.authorSeremba, Emmanuel
dc.contributor.authorAjal, Paul
dc.contributor.authorApica, Betty Stephanie
dc.contributor.authorOdongo Aginya, Emmanuel
dc.date.accessioned2022-05-01T21:07:08Z
dc.date.available2022-05-01T21:07:08Z
dc.date.issued2017
dc.description.abstractBoth Human Immunodeficiency Virus (HIV) and S.mansoni infections are common in Uganda and can cause liver disease. No study has determined co-infection significance in Uganda. We carried out a study on the burden, pattern and factors that contribute to peri-portal fibrosis (PPF) in HIV infected patients attending a Primary healthcare setting at Pakwach. Methodology: We conducted a cross-sectional study in the HIV clinic at Pakwach health centre IV. Data on demographics, contact with the Nile, CD4+ cell count, ART and alcohol use were collected. Urinary Circulating Cathodic Antigen (CCA), was done for S. Mansoni detection. Liver scan was done for presence and pattern of PPF. HBsAg testing was performed on all participants. Data was analyzed using Stata Version 10. Results: We enrolled 299 patients, median age 39 years (IQR 16), most were female, 210 (73%). Overall, 206 (68.9%) had PPF, majority 191 (92.7%) had pattern c, either alone (63 participants) or in combination with pattern d (128 participants). Age of 30-50 years was significantly associated with PPF (OR 2.28 p-value-0.003) Conclusion: We found high prevalence of S. mansoni and PPF in the HIV infected population and age was a significant factor for PPF. We recommend all HIV infected patients be examined routinely for S. mansoni infection for early anti-schistosomal treatment.en_US
dc.identifier.citationOcama P, Opio KC, Seremba E, Ajal P, Apica BS, Aginya EO. The burden, pattern and factors that contribute to periportal fibrosis in HIV-infected patients in an S. mansoni endemic rural Uganda. Afri Health Sci. 2017;17(2): 301-307. https://dx.doi.org/10.4314/ahs.v17i2.2en_US
dc.identifier.urihttps://dx.doi.org/10.4314/ahs.v17i2.2
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3100
dc.language.isoenen_US
dc.publisherAfrican Health Sciencesen_US
dc.subjectHIVen_US
dc.subjectS.Mansonien_US
dc.subjectPeri-portal fibrosis.en_US
dc.titleThe burden, pattern and factors that contribute to periportal fibrosis in HIV-infected patients in an S. mansoni endemic rural Uganda.en_US
dc.typeArticleen_US
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