High Levels of Antibiotic Resistance Patterns in Two Referral Hospitals during the Post-Ebola Era in Free-Town, Sierra Leone: 2017–2019

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dc.contributor.authorKoroma, Zikan
dc.contributor.authorMoses, Francis
dc.contributor.authorDelamou, Alexandre
dc.contributor.authorHann, Katrina
dc.contributor.authorAli, Engy
dc.contributor.authorKitutu, Freddy Eric
dc.contributor.authorNamugambe, Juliet Sanyu
dc.contributor.authorHarding, Doris
dc.contributor.authorHermans, Veerle
dc.contributor.authorTakarinda, Kudakwashe
dc.date.accessioned2022-02-03T13:21:32Z
dc.date.available2022-02-03T13:21:32Z
dc.date.issued2021
dc.description.abstractThe Post-Ebola era (2017–2019) presented an opportunity for laboratory investments in Sierra Leone. US CDC supported the Ministry of Health and Sanitation to establish a microbiological unit for routine antimicrobial sensitivity testing in two referral (pediatric and maternity) hospitals in Freetown. This study describes resistance patterns among patients’ laboratory samples from 2017 to 2019 using routine data. Samples included urine, stool, cerebrospinal fluid, pus-wound, pleural fluid, and high vaginal swabs. Selected Gram-positive and Gram-negative bacterial isolates were tested for antimicrobial susceptibility. Of 200 samples received by the laboratory, 89 returned positive bacterial isolates with urine and pus-wound swabs accounting for 75% of positive isolates. The number of positive isolates increased annually from one in 2017 to 42 in 2018 and 46 in 2019. Resistance of the cultures to at least one antibiotic was high (91%), and even higher in the pediatric hospital (94%). Resistance was highest with penicillin (81%) for Gram-positive bacteria and lowest with nitrofurantoin (13%). Gram-negative bacteria were most resistant to ampicillin, gentamycin, streptomycin, tetracycline, cephalothin and penicillin (100%) and least resistant to novobiocin (0%). Antibiotic resistance for commonly prescribed antibiotics was high in two referral hospitals, highlighting the urgent need for antimicrobial stewardship and access to reserve antibiotics.en_US
dc.identifier.citationKoroma, Z.; Moses, F.; Delamou, A.; Hann, K.; Ali, E.; Kitutu, F.E.; Namugambe, J.S.; Harding, D.; Hermans, V.; Takarinda, K.; et al. High Levels of Antibiotic Resistance Patterns in Two Referral Hospitals during the Post-Ebola Era in Free-Town, Sierra Leone: 2017–2019. Trop. Med. Infect. Dis. 2021, 6, 103. https://doi.org/10.3390/tropicalmed 6020103en_US
dc.identifier.urihttps://doi.org/10.3390/tropicalmed 6020103
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1827
dc.language.isoenen_US
dc.publisherTropical Medicine & Infection Diseaseen_US
dc.subjectAMRen_US
dc.subjectLaboratoryen_US
dc.subjectAMR surveillanceen_US
dc.subjectAntimicrobial stewardshipen_US
dc.subjectOperational researchen_US
dc.subjectSORT ITen_US
dc.subjectSierra Leoneen_US
dc.titleHigh Levels of Antibiotic Resistance Patterns in Two Referral Hospitals during the Post-Ebola Era in Free-Town, Sierra Leone: 2017–2019en_US
dc.typeArticleen_US
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