Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster

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dc.contributor.authorAyikobua, Emmanuel Tiyo
dc.contributor.authorKasolo, Josephine
dc.contributor.authorKasozi, Keneth Iceland
dc.contributor.authorEze, Ejike Daniel
dc.contributor.authorSafiriyu, Abass
dc.contributor.authorNinsiima, Herbert Izo
dc.contributor.authorKiyimba, Kennedy
dc.contributor.authorNamulema, Jackline
dc.contributor.authorJjesero, Edward
dc.contributor.authorSsempijja, Fred
dc.contributor.authorSemuyaba, Ibrahim
dc.contributor.authorKimanje, Kyobe Ronald
dc.contributor.authorKalange, Muhamudu
dc.contributor.authorOkpanachi, Alfred Omachonu
dc.contributor.authorNansunga, Miriam
dc.date.accessioned2022-09-13T17:39:12Z
dc.date.available2022-09-13T17:39:12Z
dc.date.issued2020
dc.description.abstractThe Phosphatase and tensin-induced putative kinase 1 (PINK1B9) mutant for Drosophila melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism and its possible remedy. This research was targeted toward determining the effects of ethanolic extract of propolis, with levodopa therapy in the management of Parkinsonism. The PINK1B9 flies were divided into groups and fed with the different treatment doses of ethanoic extract of propolis. The treatment groups were subjected to 21 days of administration of propolis and the levodopa at different doses after which percentage climbing index, antioxidant activity and lifespan studies were done.Propolis alone improved motor activity, antioxidant and lifespan in Drosophila melanogaster than in PINK1 flies. Propolis in combination with levodopa significantly (P<0.05) improved physiological parameters at higher than lower concentrations in Parkinsonism Drosophila melanogaster demonstrating its importance in managing side effects associated with levodopa. Propolis is a novel candidate as an alternative and integrative medicinal option to use in the management of Parkinsonism in both animals and humans at higher concentrations.en_US
dc.identifier.citationAyikobua, E. T., Kasolo, J., Kasozi, K. I., Eze, E. D., Safiriyu, A., Ninsiima, H. I., ... & Nansunga, M. (2020). Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster. Journal of Complementary and Integrative Medicine, 17(3).en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4707
dc.language.isoenen_US
dc.publisherJournal of Complementary and Integrative Medicineen_US
dc.subjectaging; antioxidant activity; catalase; climbing index; Drosophila melanogaster; Levodopa induced dyskinesia; lifespan; oxidative stress; Parkinson’s disease; Parkinsonism; PINK1B9; propolisen_US
dc.titleSynergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogasteren_US
dc.typeArticleen_US
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