Decreased Monocyte Activation with daily Acyclovir use in HIV-1/HSV-2 Coinfected Women

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dc.contributor.authorRedd, Andrew D.
dc.contributor.authorNalugoda, Fred
dc.contributor.authorSsebbowa, Paschal
dc.contributor.authorKalibbala, Sarah
dc.date.accessioned2022-11-24T11:21:52Z
dc.date.available2022-11-24T11:21:52Z
dc.date.issued2015
dc.description.abstractSeveral clinical trials have demonstrated that daily treatment of HIV-infected individuals with the antiherpes drug acyclovir slightly decreases HIV-1 viral load and slows disease progression. This study examines if this slowing in clinical progression is a direct cause of the decrease in viral load or an indirect effect of lower immune activation due to lower levels of herpetic reactivation. Women who participated in a randomised clinical trial of daily acyclovir use (n=301) were monitored every 6 months for changes in immune activation. Soluble CD14 (sCD14), a marker for monocyte activation, and C-reactive protein (CRP), a marker for general immune activation, were measured by ELISA.Initial levels of sCD14 and CRP were not predictive of HIV disease progression when controlling for initial CD4+ cell count and HIV viral load. sCD14 levels, but not CRP, decreased in the acyclovir treatment arm at a significantly faster rate than the placebo group, which was independent of changes in HIV viral load and CD4+ cell count in a multivariant mixed-effects model (p=0.039). However, the magnitude of this decrease was relatively small with a total estimated decrease of sCD14 of 15% of initial levels.These data suggest that decreased monocyte activation may play a minor role in the ability of daily acyclovir use to slow HIV disease progression.en_US
dc.identifier.citationRedd, A. D., Newell, K., Patel, E. U., Nalugoda, F., Ssebbowa, P., Kalibbala, S., ... & Reynolds, S. J. (2015). Decreased monocyte activation with daily acyclovir use in HIV-1/HSV-2 coinfected women. Sexually transmitted infections, 91(7), 485-488.http://dx.doi.org/10.1136/sextrans-2014-051867en_US
dc.identifier.issn1472-3263
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/5415
dc.language.isoenen_US
dc.publisherSexually transmitted infectionsen_US
dc.titleDecreased Monocyte Activation with daily Acyclovir use in HIV-1/HSV-2 Coinfected Womenen_US
dc.typeArticleen_US
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