Capacity building for the clinical investigation of AIDS malignancy in East Africa

dc.contributor.authorBanura MB, Cecily ChBc
dc.contributor.authorKatongole-Mbidde MB, Edward ChBc
dc.contributor.authorJohnson MDf, John L.
dc.contributor.authorAyers MDh, Leona
dc.contributor.authorGhannoum PhDc, Mahmoud
dc.contributor.authorFu PhDc, Pingfu
dc.contributor.authorFeigal MDl, Ellen G
dc.contributor.authorBlack PhDl, Jodi
dc.contributor.authorWhalen MD, Christopher MSa
dc.contributor.authorLederman MDc, Michael
dc.contributor.authorRemick MD, Scot C.
dc.contributor.authorOrem MB, Jackson ChB, MMeda
dc.contributor.authorOtieno MB, Mwanda W. ChB, MDc
dc.date.accessioned2022-02-10T23:53:44Z
dc.date.available2022-02-10T23:53:44Z
dc.date.issued2004-10-08
dc.description.abstractAbstract Purpose: To build capacity in the resource-poor setting to support the clinical investigation and treatment of AIDS-related malignancies in a region of the world hardest hit by the AIDS pandemic. Methods: An initial MEDLINE database search for international collaborative partnerships dedicated to AIDS malignancies in developing countries failed to identify any leads. This search prompted us to report progress on our collaboration in this aspect of the epidemic. Building on the formal Uganda-Case Western Reserve University (Case) Research Collaboration dating back to 1987, established NIH-supported centers of research excellence at Case, and expanding activities in Kenya, scientific and training initiatives, research capital amongst our institutions are emerging to sustain a international research enterprise focused on AIDS and other viral-related malignancies. Results: A platform of clinical research trials with pragmatic design has been developed to further enhance clinical care and sustain training initiatives with partners in East Africa and the United States. An oral chemotherapy feasibility trial in AIDS lymphoma is near completion; a second lymphoma trial of byrostatin and vincristine is anticipated and a feasibility trial of indinavir for endemic Kaposi's sarcoma is planned. Conclusions: In the absence of published reports of evolving international partnerships dedicated to AIDS malignancy in resource constrained settings, we feel it important for such progress on similar or related international collaborative pursuits to be published. The success of this effort is realized by the long-term international commitment of the collaborating investigators and institutions to sustain this effort in keeping with ethical and NIH standards for the conduct of research; the provision of formal training of investigators and research personnel on clinical problems our East African partners are faced with in practice and the development of pragmatic clinical trials and therapeutic intervention to facilitate technology transfer and enhance clinical practice.en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2052
dc.language.isoen_USen_US
dc.publisherELSEVIERen_US
dc.subjectclinical investigationen_US
dc.subjectAIDS malignancyen_US
dc.subjectEast Africaen_US
dc.subjectCapacity buildingen_US
dc.titleCapacity building for the clinical investigation of AIDS malignancy in East Africaen_US
dc.typeArticleen_US
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