Tuberculosis and human immunodeficiency virus co-infections and their predictors at a hospital-based HIV/AIDS clinic in Uganda

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dc.contributor.authorNakanjako, D.
dc.contributor.authorMayanja-Kizza, H.
dc.contributor.authorOuma, J.
dc.contributor.authorWanyenze, R.
dc.contributor.authorMwesigire, D.
dc.contributor.authorNamale, A.
dc.contributor.authorSsempiira, J.
dc.contributor.authorSenkusu, J.
dc.contributor.authorColebunders, R.
dc.contributor.authorKamya, M. R.
dc.date.accessioned2022-01-08T11:06:33Z
dc.date.available2022-01-08T11:06:33Z
dc.date.issued2010
dc.description.abstractTo evaluate the burden of TB-HIV (tuberculosis-human immunodeficiency virus) co-infections and their predictors in an urban hospital-based HIV programme. DESIGN: Prospective observational study. METHODS: Clinicians screened all patients with HIV/ AIDS (acquired immune-deficiency syndrome) for previous and current TB treatment at enrolment and through- out follow-up. RESULTS: Of 10 924 patients enrolled between August 2005 and February 2009, co-prevalent TB was 157/10 924 (1.4%), which included 88/157 (56%) with TB con- firmed at enrolment and 65/157 (41%) with TB diagnoses established during follow-up in whom symptoms were present at enrolment. Male sex (adjusted odds ratio [aOR] 2.3, 95%CI 1.6–3.2) and body mass index (BMI) ⩽20 kg/m2 (aOR 3.8, 95%CI 2.5–5.4) were associated with co-prevalent TB. Overall, 749/10 767 (7%) were diagnosed with incident TB at a higher rate among anti- retroviral treatment (ART) patients (8/100 patient years of observation [PYO]) than non-ART patients (5/100 PYO, log rank P < 0.001). Female sex (adjusted hazard ratio [aHR] 1.4, 95%CI 1.2–1.7) and baseline BMI ⩽ 20 (aHR 1.9, 95%CI 1.6–2.2) predicted incident TB. CONCLUSION: Routine TB screening in the HIV/AIDS care programme identified a significant number of TB- HIV co-infections among patients with and without ART, and is therefore a potential strategy to improve HIV treatment outcomes in resource-limited settings.en_US
dc.identifier.citationNakanjako, D., Mayanja-Kizza, H., Ouma, J., Wanyenze, R., Mwesigire, D., Namale, A., ... & Kamya, M. R. (2010). Tuberculosis and human immunodeficiency virus co-infections and their predictors at a hospital-based HIV/AIDS clinic inUganda. The International journal of tuberculosis and lung disease, 14(12), 1621-1628.en_US
dc.identifier.urihttps://www.ingentaconnect.com/content/iuatld/ijtld/2010/00000014/00000012/art00021
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1172
dc.language.isoenen_US
dc.publisherThe International journal of tuberculosis and lung diseaseen_US
dc.subjectHIV/AIDSen_US
dc.subjectTB-HIV co-infectionsen_US
dc.subjectTuberculosisen_US
dc.subjectARTen_US
dc.subjectAfricaen_US
dc.titleTuberculosis and human immunodeficiency virus co-infections and their predictors at a hospital-based HIV/AIDS clinic in Ugandaen_US
dc.typeArticleen_US
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