Serum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Study

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dc.contributor.authorJain, Raghav
dc.contributor.authorEzeamama, Amara
dc.contributor.authorSikorskii, Alla
dc.contributor.authorYakah, William
dc.contributor.authorZalwango, Sarah
dc.contributor.authorMusoke, Philippa
dc.contributor.authorBoivin, Michael
dc.contributor.authorFenton, Jenifer
dc.date.accessioned2021-12-09T08:48:36Z
dc.date.available2021-12-09T08:48:36Z
dc.date.issued2019
dc.description.abstractFatty acids (FAs) are crucial in child growth and development. In Uganda, antiretroviral therapy (ART) has drastically reduced perinatal human immunodeficiency virus (HIV) infection of infants, however, the interplay of FAs, ART, and HIV in relation to child growth is not well understood. To investigate this, serum was collected from 240 children between 6–10 years old in Uganda and analyzed for FAs using gas-chromatography mass-spectrometry. HIV status and anthropometric measurements were taken, and relationships with FAs were assessed. No significant differences in growth parameters or serum FAs were found between HIV uninfected children with and without exposure to ART. HIV positive children had significantly lower height-for-age-z-scores (HAZ) than uninfected children (p < 0.001). HIV-positive children had higher arachidonic acid than uninfected children (p = 0.003). Total omega-6 FAs were significantly associated with HAZ regardless of HIV status (p = 0.035). Mean total omega-3 FAs (2.90%) were low in this population compared to other cohorts in Africa. These results provide reference serum FA values for 6–10-year-old children in Uganda and may be used to inform lipid supplementation programs to promote child growth. Future studies should investigate the relationships between child growth trajectories in relation to HIV status and serum FAs.en_US
dc.identifier.citationJain, R., Ezeamama, A. E., Sikorskii, A., Yakah, W., Zalwango, S., Musoke, P., ... & Fenton, J. I. (2019). Serum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Study. Nutrients, 11(6), 1268.en_US
dc.identifier.uri10.3390/nu11061268
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/215
dc.language.isoenen_US
dc.publisherLicensee MDPIen_US
dc.subjectFatty Acidsen_US
dc.subjectHIVen_US
dc.subjectUgandaen_US
dc.subjectArachidonicen_US
dc.subjectOmega-3en_US
dc.subjectOmega-6en_US
dc.titleSerum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Studyen_US
dc.typeArticleen_US
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