Serotype Specificity of Antibodies against Foot-and-Mouth Disease Virus in Cattle in Selected Districts in Uganda

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dc.contributor.authorMwiine, F. N.
dc.contributor.authorAyebazibwe, C.
dc.contributor.authorMukani, W. Olaho
dc.contributor.authorAlexandersen, S.
dc.contributor.authorBalinda, S. N.
dc.contributor.authorMasembe, C.
dc.contributor.authorOkurut, A. R. Ademun
dc.contributor.authorChristensen, L. S.
dc.contributor.authorSørensen, K. J.
dc.date.accessioned2022-02-23T10:24:40Z
dc.date.available2022-02-23T10:24:40Z
dc.date.issued2010
dc.description.abstractUganda had an unusually large number of foot-and-mouth disease (FMD) outbreaks in 2006, and all clinical reports were in cattle. A serological investigation was carried out to confirm circulating antibodies against foot-and-mouth disease virus (FMDV) by ELISA for antibodies against non-structural proteins and structural proteins. Three hundred and forty-nine cattle sera were collected from seven districts in Uganda, and 65% of these were found positive for antibodies against the non-structural proteins of FMDV. A subset of these samples were analysed for serotype specificity of the identified antibodies. High prevalences of antibodies against non-structural proteins and structural proteins of FMDV serotype O were demonstrated in herds with typical visible clinical signs of FMD, while prevalences were low in herds without clinical signs of FMD. Antibody titres were higher against serotype O than against serotypes SAT 1, SAT 2 and SAT 3 in the sera investigated for serotype-specific antibodies. Only FMDV serotype O virus was isolated from one probang sample. This study shows that the majority of the FMD outbreaks in 2006 in the region studied were caused by FMDV serotype O; however, there was also evidence of antibodies to both SAT 1 and SAT 3 in one outbreak in a herd inside Queen Elizabeth national park area.en_US
dc.identifier.citationMwiine, F. N., Ayebazibwe, C., Olaho‐Mukani, W., Alexandersen, S., Balinda, S. N., Masembe, C., ... & Tjørnehøj, K. (2010). Serotype specificity of antibodies against foot‐and‐mouth disease virus in cattle in selected districts in Uganda. Transboundary and Emerging Diseases, 57(5), 365-374.https://doi.org/10.1111/j.1865-1682.2010.01157.xen_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2272
dc.language.isoenen_US
dc.publisherTransboundary and Emerging Diseasesen_US
dc.titleSerotype Specificity of Antibodies against Foot-and-Mouth Disease Virus in Cattle in Selected Districts in Ugandaen_US
dc.title.alternative2010en_US
dc.typeArticleen_US
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