Cardiovascular risk factors among people with drug-resistant tuberculosis in Uganda

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dc.contributor.authorBaruch Baluku, Joseph
dc.contributor.authorNabwana, Martin
dc.contributor.authorNalunjogi, Joanitah
dc.contributor.authorMuttamba, Winters
dc.contributor.authorMubangizi, Ivan
dc.contributor.authorNakiyingi, Lydia
dc.contributor.authorSsengooba, Willy
dc.contributor.authorOlum, Ronald
dc.contributor.authorBongomin, Felix
dc.contributor.authorAndia-Biraro, Irene
dc.contributor.authorWorodria, William
dc.date.accessioned2023-01-22T12:05:08Z
dc.date.available2023-01-22T12:05:08Z
dc.date.issued2022
dc.description.abstractTuberculosis (TB) and its risk factors are independently associated with cardiovascular disease (CVD). We determined the prevalence and associations of CVD risk factors among people with drug-resistant tuberculosis (DRTB) in Uganda. Methods In this cross-sectional study, we enrolled people with microbiologically confirmed DRTB at four treatment sites in Uganda between July to December 2021. The studied CVD risk factors were any history of cigarette smoking, diabetes mellitus (DM) hypertension, high body mass index (BMI), central obesity and dyslipidaemia. We used modified Poisson regression models with robust standard errors to determine factors independently associated with each of dyslipidaemia, hypertension, and central obesity. Results Among 212 participants, 118 (55.7%) had HIV. Overall, 196 (92.5%, 95% confidence interval (CI) 88.0-95.3) had ≥ 1 CVD risk factor. The prevalence; 95% CI of individual CVD risk factors was: dyslipidaemia (62.5%; 55.4–69.1), hypertension (40.6%; 33.8–47.9), central obesity (39.3%; 32.9–46.1), smoking (36.3%; 30.1–43.1), high BMI (8.0%; 5.0–12.8) and DM (6.5%; 3.7–11.1). Dyslipidaemia was associated with an increase in glycated haemoglobin (adjusted prevalence ratio (aPR) 1.14, 95%CI 1.06–1.22). Hypertension was associated with rural residence (aPR 1.89, 95% CI 1.14– 3.14) and previous history of smoking (aPR 0.46, 95% CI 0.21–0.98). Central obesity was associated with increasing age (aPR 1.02, 95%CI 1.00–1.03), and elevated diastolic blood pressure (aPR 1.03 95%CI 1.00–1.06). Conclusion There is a high prevalence of CVD risk factors among people with DRTB in Uganda, of which dyslipidaemia is the commonest. We recommend integrated services for identification and management of CVD risk factors in DRTB.en_US
dc.identifier.citationBaluku, J. B., Nabwana, M., Nalunjogi, J., Muttamba, W., Mubangizi, I., Nakiyingi, L., ... & Worodria, W. (2022). Cardiovascular risk factors among people with drug-resistant tuberculosis in Uganda. BMC Cardiovascular Disorders, 22(1), 1-10. https://doi.org/10.1186/s12872-022-02889-yen_US
dc.identifier.urihttps://doi.org/10.1186/s12872-022-02889-y
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7099
dc.language.isoenen_US
dc.publisherBMC Cardiovascular Disordersen_US
dc.subjectSmokingen_US
dc.subjectDiabetesen_US
dc.subjectHypertensionen_US
dc.subjectLipidsen_US
dc.subjectTBen_US
dc.subjectCardiovascularen_US
dc.subjectCholesterolen_US
dc.subjectObesityen_US
dc.subjectMDR TBen_US
dc.titleCardiovascular risk factors among people with drug-resistant tuberculosis in Ugandaen_US
dc.typeArticleen_US
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