Cognitive Impairment After Cerebral Malaria In Children: A Prospective Study

Simple item page
dc.contributor.authorBoivin, Michael J.
dc.contributor.authorBangirana, Paul
dc.contributor.authorByarugaba, Justus
dc.contributor.authorOpoka, Robert O.
dc.contributor.authorIdro, Richard
dc.contributor.authorJurek, Anne M.
dc.contributor.authorJohn, Chandy C.
dc.date.accessioned2022-02-08T18:43:39Z
dc.date.available2022-02-08T18:43:39Z
dc.date.issued2007
dc.description.abstractThis study was conducted to assess prospectively the frequency of cognitive deficits in children with cerebral malaria.Cognitive testing in the areas of working memory, attention, and learning was performed for Ugandan children 5 to 12 years of age with cerebral malaria (n = 44), children with uncomplicated malaria (n = 54), and healthy community children (n = 89) at admission and 3 and 6 months later.Six months after discharge, 21.4% of children with cerebral malaria had cognitive deficits, compared with 5.8% of community children. Deficits were seen in the areas of working memory (11.9% vs 2.3%) and attention (16.7% vs 2.3%). Children with cerebral malaria had a 3.7-fold increased risk of a cognitive deficit, compared with community children, after adjustment for age, gender, nutritional status, school level, and home environment. Among children with cerebral malaria, those with a cognitive deficit had more seizures before admission (mean: 4.1 vs 2.2) and a longer duration of coma (43.6 vs 30.5 hours), compared with those without a deficit. Children with uncomplicated malaria did not have an increased frequency of cognitive deficits.Cerebral malaria may be a major cause of cognitive impairment in children in sub-Saharan Africa. Cognitive deficits in children with cerebral malaria are more likely for those who have multiple seizures before effective treatment for cerebral malaria.en_US
dc.identifier.citationBoivin, M. J., Bangirana, P., Byarugaba, J., Opoka, R. O., Idro, R., Jurek, A. M., & John, C. C. (2007). Cognitive impairment after cerebral malaria in children: a prospective study. Pediatrics, 119(2), e360-e366.https://doi.org/10.1542/peds.2006-2027en_US
dc.identifier.issn1098-4275
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2005
dc.language.isoenen_US
dc.publisherPediatricsen_US
dc.subjectcerebral malaria; cognitive; deficit; impairment; sequelaeen_US
dc.titleCognitive Impairment After Cerebral Malaria In Children: A Prospective Studyen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Cognitive Impairment After Cerebral Malaria In Children A.pdf
Size:
62.4 KB
Format:
Adobe Portable Document Format
Description:
Cognitive Impairment After Cerebral Malaria In Children: A Prospective Study
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences