Hepatitis B virus and HIV infection among patients with primary hepatocellular carcinoma in Kampala, Uganda

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dc.contributor.authorOcama, P.
dc.contributor.authorOpio, K. C.
dc.contributor.authorKagimu, M.
dc.contributor.authorSeremba, E.
dc.contributor.authorWabinga, H.
dc.contributor.authorColebunders, R.
dc.date.accessioned2022-05-01T13:49:49Z
dc.date.available2022-05-01T13:49:49Z
dc.date.issued2011
dc.description.abstractHepatitis B virus (HBV) is the commonest cause of primary hepatocellular (PHC) carcinoma worldwide. Coinfection with the HIV leads to more rapid progression of liver disease. Objectives: We described prevalence of HBV and HIV among patients with PHC admitted to Mulago Hospital, Kampala, Uganda. Methods: We assessed all patients admitted to the gastrointestinal service of Mulago hospital with a diagnosis of PHC for HBV and HIV infection. Results: From March to June 2008, we recruited 15 patients. Nine (60%) were male; the overall median age was 32 years (IQR 15 -67), with median ages for male and female 33 and 36 years respectively. Alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and AFP were all elevated with median values of 57.5 IU/L, 222 IU/L, 392 IU/L and 362 ng/ml respectively (IQR 14-145, 49-393, 165-1294 and 7-480). Eight (53%) patients were from North and Northeastern Uganda. The HBsAg was reactive in 13(87%) patients and HIV in 3(20%), all of whom were also co-infected with HBV. Conclusion: There is high prevalence of HBV and HBV/HIV co-infection among patients with PHC in Uganda with high mortality. Reduction in incidence and mortality due to PHC in Uganda will require urgent large scale HBV vaccination.en_US
dc.identifier.citationOcama, P., Opio, K. C., Kagimu, M., Seremba, E., Wabinga, H., & Colebunders, R. (2011). Hepatitis B virus and HIV infection among patients with primary hepatocellular carcinoma in Kampala, Uganda. African health sciences, 11, 20-23.en_US
dc.identifier.urihttps://www.ajol.info/index.php/ahs/article/view/70065
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3088
dc.language.isoenen_US
dc.publisherAfrican health sciencesen_US
dc.subjectHepatitis Ben_US
dc.subjectHIVen_US
dc.subjectPrimary Hepatocelular Carcinomaen_US
dc.titleHepatitis B virus and HIV infection among patients with primary hepatocellular carcinoma in Kampala, Ugandaen_US
dc.typeArticleen_US
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