Predictors of Isoniazid Preventive Therapy Completion Among HIV-Infected Patients Receiving Differentiated and non-Differentiated HIV Care in Rural Uganda

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dc.contributor.authorTram, Khai Hoan
dc.contributor.authorMwangwa, Florence
dc.contributor.authorChamie, Gabriel
dc.contributor.authorAtukunda, Mucunguzi
dc.contributor.authorOwaraganise, Asiphas
dc.contributor.authorAyieko, James
dc.contributor.authorJain, Vivek
dc.contributor.authorTamara, D. Clark
dc.contributor.authorKwarisiima, Dalsone
dc.contributor.authorMaya, L. Petersen
dc.contributor.authorKamya, Moses R.
dc.contributor.authorCharlebois, Edwin D.
dc.contributor.authorHavlir, Diane V.
dc.contributor.authorMarquez, Carina
dc.contributor.authorSEARCH collaboration
dc.date.accessioned2022-08-24T20:59:25Z
dc.date.available2022-08-24T20:59:25Z
dc.date.issued2020
dc.description.abstractRates of Isoniazid Preventive Therapy (IPT) completion remain low in programmatic settings in sub-Saharan Africa. Differentiated HIV care models may improve IPT completion by addressing joint barriers to IPT and HIV treatment. However, the impact of differentiated care on IPT completion remains unknown. In a cross-sectional study of people with HIV on antiretroviral therapy in 5 communities in rural Uganda, we compared IPT completion between patients receiving HIV care via a differentiated care model versus a standard HIV care model and assessed multi-level predictors of IPT completion. A total of 103/144 (72%) patients received differentiated care and 85/161 (53%) received standard care completed IPT (p < 0.01). Adjusting for age, gender and community, patients receiving differentiated care had higher odds of completing IPT (aOR: 2.6, 95% CI: 1.5–4.5, p < 0.01). Predictors of IPT completion varied by the care model, and differentiated care modified the positive association between treatment completion and the belief in the efficacy of IPT and the negative association with side-effects. Patients receiving a multi-component differentiated care model had a higher odds of IPT completion than standard care, and the model’s impact on health beliefs, social support, and perceived side effects to IPT may underlie this positive association.en_US
dc.identifier.citationTram, K. H., Mwangwa, F., Chamie, G., Atukunda, M., Owaraganise, A., Ayieko, J., ... & SEARCH collaboration. (2020). Predictors of isoniazid preventive therapy completion among HIV-infected patients receiving differentiated and non-differentiated HIV care in rural Uganda. AIDS care, 32(1), 119-127.https://doi.org/10.1080/09540121.2019.1619661en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4417
dc.language.isoenen_US
dc.publisherAIDS careen_US
dc.subjectIsoniazid Preventive Therapy; TB prevention; East Africa; HIV; Differentiated Careen_US
dc.titlePredictors of Isoniazid Preventive Therapy Completion Among HIV-Infected Patients Receiving Differentiated and non-Differentiated HIV Care in Rural Ugandaen_US
dc.typeArticleen_US
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