Risk Of Being Seropositive For Multiple Human Papillomavirus Types Among Finnish And Ugandan Women
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Date
2010
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Scandinavian journal of infectious diseases
Abstract
Although infections with multiple human papillomavirus (HPV) types have been reported widely, more information is needed
on the occurrence of the different types. We determined the distribution of seroprevalences to multiple HPV types in Finland
and Uganda to compare the epidemiology of the different HPV types in the 2 populations. Serum samples were obtained
from 2784 Finnish and 1964 Ugandan women (mean ages 22 y and 25 y, respectively) of whom 44% and 57%, respectively,
had antibodies to at least 1 of the 7 HPV types (6, 11, 16, 18, 31, 33, 45) tested ( p 0.001). Multiple HPV antibody positivity
was common. HPV45-seropositive Finns had a higher risk of having antibodies to other high-risk HPV types: HPV18 (odds
ratio (OR) 10.9), HPV31 (OR 6.1), HPV33 (OR 12.2), than their Ugandan counterparts: HPV18 (OR 3.4), HPV31 (OR 2.2),
HPV33 (OR 3.3). Increased estimates for being double antibody-positive were also noted among HPV18- and HPV16-
seropositive women, but there were no major differences between HPV16-seropositive Finns and Ugandans. In addition to
biological and behavioural factors, iatrogenic and societal factors (screening vs no screening) may also result in the different
occurrence of infections with the high-risk HPV types in Finland and Uganda.
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Citation
Namujju, P. B., Surcel, H. M., Kirnbauer, R., Kaasila, M., Banura, C., Byaruhanga, R., ... & Lehtinen, M. (2010). Risk of being seropositive for multiple human papillomavirus types among Finnish and Ugandan women. Scandinavian journal of infectious diseases, 42(6-7), 522-526.https://doi.org/10.3109/00365540903582426