Alobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Uganda

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dc.contributor.authorSikakulya, Franck Katembo
dc.contributor.authorKiyaka, Sonye Magugu
dc.contributor.authorMasereka, Robert
dc.contributor.authorSsebuufu, Robinson
dc.date.accessioned2023-03-20T09:34:46Z
dc.date.available2023-03-20T09:34:46Z
dc.date.issued2021
dc.description.abstractHoloprosencephaly (HPE) is a rare cerebrofacial abnormality resulting from the complete or partial failure of the diverticulation and cleavage of the primitive forebrain. It has an incidence at birth of 1:16000. Case Presentation. We report a case of a 2600 g newborn female delivered by an HIV-infected mother in whom an antenatal ultrasound scan at 34 weeks’ gestation reported features of fetal alobar holoprosencephaly. The neonate was born with cebocephaly, a monkey-like head, and did not survive for more than 30 minutes following delivery by caesarian section despite oxygen therapy. Conclusion. Alobar HPE with cebocephaly remains incompatible with life. In this resource-limited setting, the diagnosis was made clinically, and only an ultrasound scan was performed to confirm the diagnosis. Chromosomal analysis could have given more information.en_US
dc.identifier.citationSikakulya, F. K., Kiyaka, S. M., Masereka, R., & Ssebuufu, R. (2021). Alobar holoprosencephaly with cebocephaly in a neonate born to an HIV-positive mother in Eastern Uganda. Case Reports in Otolaryngology, 2021.https://doi.org/10.1155/2021/7282283en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8242
dc.language.isoenen_US
dc.publisherCase Reports in Otolaryngologyen_US
dc.subjectAlobar Holoprosencephalyen_US
dc.subjectCebocephalyen_US
dc.subjectNeonate Bornen_US
dc.subjectHIV-Positive Motheren_US
dc.titleAlobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Ugandaen_US
dc.typeTechnical Reporten_US
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