Incidence of the Metabolic Syndrome among Patients with Epilepsy Attending a Neuropsychiatric Hospital in Kigali, Rwanda

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dc.contributor.authorNdayambaje, François Xavier
dc.contributor.authorGahutu, Jean Bosco
dc.contributor.authorRugera, Simon Peter
dc.contributor.authorNatukunda, Bernard
dc.date.accessioned2022-01-24T13:42:52Z
dc.date.available2022-01-24T13:42:52Z
dc.date.issued2021
dc.description.abstractMetabolic syndrome (MetS), a combination of diverse metabolic disorders (hypertension, diabetes mellitus, high triglycerides, increased waist circumference, and low high density cholesterol, HDLc), is a well known public health problem worldwide, and its prevalence is increasing dramatically. MetS is a confirmed great risk factor for cardiovascular diseases. Presently, limited information exists about incidence and the risk factors associated with metabolic syndrome (MetS) in patients with epilepsy. We prospectively estimated the incidence of MetS in patients with epilepsy.We recruited 322 participants, 161 patients with epilepsy and 161 healthy volunteers all of them free of any MetS criteria at the baseline and followed-up them for one year. New onset cases of MetS were defined according to the updated National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATPIII) criteria. Over a 1-year follow-up, we observed 8 incident cases of MetS (7 individuals in patients group and 1 individual in control group) resulting in an annual cumulative incidence rate of 2.5%. We observed 9 cases losses to follow up. Patients with epilepsy presented a higher risk of developing MetS (RR=7.00, 95% CI: 0.891 - 1.67, p=0.032) than in control group. Sedentariness was associated with higher risk for MetS (hazard ratio, HR=6.537, 95%; confidence interval, C.I=1.269-33.685, p value =0.025. Anti-epileptic therapy combined with sedentariness increases the risk of developing MetS among patients with epilepsy. Holistic clinical management of patients with epilepsy will significantly contribute to MetS prevention.en_US
dc.identifier.citationNdayambaje, F. X., Gahutu, J. B., Rugera, S. P., & Natukunda, B. Incidence of the Metabolic Syndrome among Patients with Epilepsy Attending a Neuropsychiatric Hospital in Kigali, Rwanda.DOI: 10.47191/ijcsrr/V4-i5-03, Impact Factor: 5.825en_US
dc.identifier.issn2581-8341
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1494
dc.language.isoenen_US
dc.publisherInternational Journal of Current Science Research and Reviewen_US
dc.subjectMetabolic syndrome, epilepsy, incidence, anti-epileptic drugsen_US
dc.titleIncidence of the Metabolic Syndrome among Patients with Epilepsy Attending a Neuropsychiatric Hospital in Kigali, Rwandaen_US
dc.typeArticleen_US
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