One-year Incidence and Standardized Mortality Rates for Esophageal Squamous Cell Carcinoma in Uganda

Simple item page
dc.contributor.authorOkello, Samson
dc.contributor.authorByaruhanga, Emmanuel B.
dc.contributor.authorLumori, Boniface Amanee Elias
dc.contributor.authorAkello, Suzan Joan
dc.contributor.authorDwomoh, Emmanuel
dc.contributor.authorOpio, Christopher Kenneth
dc.contributor.authorOcama, Ponsiano
dc.contributor.authorMuyindike, Winnie R.
dc.contributor.authorDavid, Christiani C.
dc.contributor.authorCorey, Kathleen E.
dc.date.accessioned2022-05-01T19:40:23Z
dc.date.available2022-05-01T19:40:23Z
dc.date.issued2021
dc.description.abstractLittle is known about the survival of patients with esophageal squamous cell cancer in resource limited settings. Objectives: We sought to determine the incidence of one-year all-cause mortality and age-standardized mortality rates for esophageal squamous cell carcinoma in Uganda. Methods: Prospective cohort of 92 participants with histologically confirmed esophageal squamous cell cancer at Mbarara Regional Referral Hospital, southwestern Uganda. Participants were enrolled between January 2018 and March 2020 and followed until death. We used Kaplan-Meier methods to determine allcause mortality and median survival time; Cox regression to determine predictors of survival; and determined age-standardized mortality rates (SMR) using the WHO standard population. Results: All 92 participants contributed a total 353.8 months at risk, 89 (96.7%) died representing an incidence rate of 251.5 (95% CI 204.3, 309.6) per 1000 person-months. The difference in the one-year risk of all-cause mortality among men and women was negative 6.4 percentage points. The overall SMR was 9.96 (95%CI 7.63, 12.29) per 100,000 and median survival time was 3.03 (95% CI 2.60, 3.47), shortest (1.77 months) among men younger than 45 and longest (7.77 months) among women aged 75 years or greater. In a fully adjusted model, high socioeconomic status predicted longer survival while increasing age and low socioeconomic status predicted shorter survival. Conclusion: After diagnosis, the one-year incidence rates of all-cause mortality and age-standardized mortality rates among ESCC patients in rural Uganda are high. Initiatives to improve access to oncology care for diagnosis and treatment should be prioritized to improve overall survival.en_US
dc.identifier.citationOkello, S., BYARUHANGA, E. B., LUMORI, B. A. E., AKELLO, S. J., DWOMOH, E., OPIO, C. K., ... & COREY, K. E. (2021). One-year incidence and standardized mortality rates for esophageal squamous cell carcinoma in Uganda. https://doi.org/10.21203/rs.3.rs-181011/v1en_US
dc.identifier.urihttps://doi.org/10.21203/rs.3.rs-181011/v1
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3089
dc.language.isoenen_US
dc.publisherResearch Squareen_US
dc.subjectEsophageal squamous cell carcinomaen_US
dc.subjectSurvivalen_US
dc.subjectUgandaen_US
dc.titleOne-year Incidence and Standardized Mortality Rates for Esophageal Squamous Cell Carcinoma in Ugandaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
One-year Incidence and Standardized Mortality.pdf
Size:
976.44 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences