Distribution of β-Thalassemia and Other Hemoglobinopathies in Bangladeshi University Students and Ready-Made Garment Workers

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dc.contributor.authorIslam, Mohammad Manirul
dc.contributor.authorHossain, Fahima
dc.contributor.authorSakib, Najmuj
dc.contributor.authorZeba, Zebunnesa
dc.contributor.authorMamun, Mohammed A.
dc.contributor.authorKaggwa, Mark Mohan
dc.contributor.authorYoshimura, Ken
dc.contributor.authorAfrin, Sadia
dc.contributor.authorSelim, Sheikh
dc.contributor.authorHossain
dc.date.accessioned2022-06-21T09:55:15Z
dc.date.available2022-06-21T09:55:15Z
dc.date.issued2021
dc.description.abstractThe inheritable thalassemia and other structural hemoglobinopathies are prevalent globally. In Bangladesh, there is a scarcity of studies concerning thalassemia and other structural hemoglobinopathies. Hence, the present study investigated the prevalence and distribution of β-thalassemia and other hemoglobinopathies among the university students and ready-made garment (RMG) workers.A cross-sectional study was conducted, whereas a total of 989 subjects were selected randomly from 10 garments industries (n=495) and five universities (n=494) for diagnosis and counseling from April 2018 to August 2018. Basic information related to the study and venous blood was collected and subjected to capillary Hb-electrophoresis for each participant. The present study identified thalassemia carriers and other hemoglobinopathies among 13.6% of the participants (14.1% university students and 13.2% RMG workers). The most common form of hemoglobin formation disorder was the Hb-E trait (10.5%), considering both participants’ groups. Other forms of hemoglobin formation disorders observed were a β-thalassemia trait, Hb-D trait, Hb-E disease, and β-thalassemia major. The hemoglobinopathies were significantly associated with the individuals who had a family history of thalassemia and were not vaccinated against hepatitis B in the total sample. Although not statistically suggestive, the most considerable portion (87.3%) of the carriers was unmarried in the present findings.The present study findings are anticipated to help the public health authorities by providing novel data (of a neglected cohort, ie, RGM workers), facilitating the upcoming comprehensive national thalassemia prevention programs.en_US
dc.identifier.citationIslam, M. M., Hossain, F., Sakib, N., Zeba, Z., Bhuiyan, A. I., Mamun, M. A., ... & Hossain, M. (2021). Distribution of β-Thalassemia and Other Hemoglobinopathies in Bangladeshi University Students and Ready-Made Garment Workers. Risk Management and Healthcare Policy, 14, 2707.https://doi.org/10.2147%2FRMHP.S317852en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4027
dc.language.isoenen_US
dc.publisherRisk Management and Healthcare Policyen_US
dc.subjectthalassemia, hemoglobinopathies, premarital carrier screening, RMG workers, thalassemia education and awareness, Bangladeshen_US
dc.titleDistribution of β-Thalassemia and Other Hemoglobinopathies in Bangladeshi University Students and Ready-Made Garment Workersen_US
dc.typeArticleen_US
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