Prevalence, antimicrobial susceptibility and risk factors associated with non-typhoidal Salmonella on Ugandan layer hen farms

Simple item page
dc.contributor.authorOdoch, Terence
dc.contributor.authorWasteson, Yngvild
dc.contributor.authorL’Abée-Lund, Trine
dc.contributor.authorMuwonge, Adrian
dc.contributor.authorKankya, Clovice
dc.contributor.authorNyakarahuka, Luke
dc.contributor.authorTegule, Sarah
dc.contributor.authorSkjerve, Eystein
dc.date.accessioned2022-02-04T17:24:15Z
dc.date.available2022-02-04T17:24:15Z
dc.date.issued2017
dc.description.abstractNon-typhoidal Salmonella (NTS) are among the leading global foodborne pathogens and a significant public health threat. Their occurrence in animal reservoirs and their susceptibilities to commonly used antimicrobials are poorly understood in developing countries. The aim of this study was to estimate the prevalence, determine antimicrobial susceptibility and identify risk factors associated with NTS presence in laying hen farms in Uganda through a cross-sectional study. Results: Pooled faecal samples were collected from 237 laying hen farms and these were analysed for NTS following standard laboratory procedures. In total, 49 farms (20.7%; 95% Confidence interval (CI): 15.6–25.6%) were positive for NTS presence. Altogether, ten Salmonella serotypes were identified among the confirmed 78 isolates, and the predominant serotypes were Salmonella Newport (30.8%), S. Hadar (14.1%), S. Aberdeen (12.8%), S. Heidelberg (12.8%), and S. Bolton (12. 8%). Phenotypic antimicrobial resistance was detected in 45(57.7%) of the isolates and the highest resistance was against ciprofloxacin (50.0%) followed by sulphonamides (26.9%) and sulphamethoxazole/trimethoprim (7.7%). Resistance was significantly associated with sampled districts (p = 0.034). Resistance to three or more drugs, multi-drug resistance (MDR) was detected in 12 (15.4%) of the isolates, 9 (75%) of these were from Wakiso district. A multivariable logistic model identified large farm size (OR = 7.0; 95% CI: 2.5–19.8) and the presence of other animal species on the farm (OR = 5.9; 95% CI: 2.1–16.1) as risk factors for NTS prevalence on farms. Having a separate house for birds newly brought to the farms was found to be protective (OR = 0,4; 95% CI: 0.2–0.8). Conclusion: This study has highlighted a high prevalence and diversity of NTS species in laying hen farms in Uganda and identified associated risk factors. In addition, it has demonstrated high levels of antimicrobial resistance in isolates of NTS. This could be because of overuse or misuse of antimicrobials in poultry production. Also importantly, the insights provided in this study justifies a strong case for strengthening One Health practices and this will contribute to the development of NTS control strategies at local, national and international levels.en_US
dc.identifier.citationOdoch, T., Wasteson, Y., L’Abée-Lund, T., Muwonge, A., Kankya, C., Nyakarahuka, L., ... & Skjerve, E. (2017). Prevalence, antimicrobial susceptibility and risk factors associated with non-typhoidal Salmonella on Ugandan layer hen farms. BMC veterinary research, 13(1), 1-10. DOI 10.1186/s12917-017-1291-1en_US
dc.identifier.other10.1186/s12917-017-1291-1
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1925
dc.language.isoenen_US
dc.publisherBMC veterinary researchen_US
dc.subjectNon-typhoidal Salmonellaen_US
dc.subjectAntimicrobial susceptibilityen_US
dc.subjectRisk factoren_US
dc.subjectLayer hensen_US
dc.subjectPrevalenceen_US
dc.titlePrevalence, antimicrobial susceptibility and risk factors associated with non-typhoidal Salmonella on Ugandan layer hen farmsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Prevalence, antimicrobial susceptibility and.pdf
Size:
443.91 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Agricultural and Veterinary Sciences